Pathophysiology of the systemic inflammatory response after major accidental trauma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Sep-15
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Vol/bind17
Udgave nummer1
Sider (fra-til)43
ISSN1757-7241
DOI
StatusUdgivet - 15. sep. 2009

Fingeraftryk

Wounds and Injuries
Clinical Trials

Citer dette

@article{acdf3b70ac2211de9743000ea68e967b,
title = "Pathophysiology of the systemic inflammatory response after major accidental trauma",
abstract = "ABSTRACT: BACKGROUND: Purpose of the present study was to describe the pathophysiology of the systemic inflammatory response after major trauma and the timing of final reconstructive surgery. Methods: An unsystematic review of the medical literature was performed and articles pertaining to the inflammatory response to trauma were obtained. The literature selected was based on the preference and clinical expertise of authors. Discussion: The inflammatory response consists of hormonal metabolic and immunological components and the extent correlates with the magnitude of the tissue injury. After trauma and uncomplicated surgery a delicate balance between pro- and anti-inflammatory mediators is observed.Trauma patients are, however, often exposed, not only to the trauma, but to several evens in the form of initial surgery and later final reconstructive surgery. In this case immune paralysis associated with increased risk of infection might develop. The inflammatory response is normalized 3 weeks following trauma. It has been proposed that the final reconstructive surgery should be postponed until the inflammatory response is normalized. This statement is however not based on clinical trials. Conclusion: Postponement of final reconstructive surgery until the inflammatory is normalized should be based on prospective randomized trials.",
author = "Br{\o}chner, {Anne Craveiro} and Palle Toft",
year = "2009",
month = "9",
day = "15",
doi = "10.1186/1757-7241-17-43",
language = "English",
volume = "17",
pages = "43",
journal = "Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine",
issn = "1757-7241",
publisher = "BioMed Central",
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}

Pathophysiology of the systemic inflammatory response after major accidental trauma. / Brøchner, Anne Craveiro; Toft, Palle.

I: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Bind 17, Nr. 1, 15.09.2009, s. 43.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Pathophysiology of the systemic inflammatory response after major accidental trauma

AU - Brøchner, Anne Craveiro

AU - Toft, Palle

PY - 2009/9/15

Y1 - 2009/9/15

N2 - ABSTRACT: BACKGROUND: Purpose of the present study was to describe the pathophysiology of the systemic inflammatory response after major trauma and the timing of final reconstructive surgery. Methods: An unsystematic review of the medical literature was performed and articles pertaining to the inflammatory response to trauma were obtained. The literature selected was based on the preference and clinical expertise of authors. Discussion: The inflammatory response consists of hormonal metabolic and immunological components and the extent correlates with the magnitude of the tissue injury. After trauma and uncomplicated surgery a delicate balance between pro- and anti-inflammatory mediators is observed.Trauma patients are, however, often exposed, not only to the trauma, but to several evens in the form of initial surgery and later final reconstructive surgery. In this case immune paralysis associated with increased risk of infection might develop. The inflammatory response is normalized 3 weeks following trauma. It has been proposed that the final reconstructive surgery should be postponed until the inflammatory response is normalized. This statement is however not based on clinical trials. Conclusion: Postponement of final reconstructive surgery until the inflammatory is normalized should be based on prospective randomized trials.

AB - ABSTRACT: BACKGROUND: Purpose of the present study was to describe the pathophysiology of the systemic inflammatory response after major trauma and the timing of final reconstructive surgery. Methods: An unsystematic review of the medical literature was performed and articles pertaining to the inflammatory response to trauma were obtained. The literature selected was based on the preference and clinical expertise of authors. Discussion: The inflammatory response consists of hormonal metabolic and immunological components and the extent correlates with the magnitude of the tissue injury. After trauma and uncomplicated surgery a delicate balance between pro- and anti-inflammatory mediators is observed.Trauma patients are, however, often exposed, not only to the trauma, but to several evens in the form of initial surgery and later final reconstructive surgery. In this case immune paralysis associated with increased risk of infection might develop. The inflammatory response is normalized 3 weeks following trauma. It has been proposed that the final reconstructive surgery should be postponed until the inflammatory response is normalized. This statement is however not based on clinical trials. Conclusion: Postponement of final reconstructive surgery until the inflammatory is normalized should be based on prospective randomized trials.

U2 - 10.1186/1757-7241-17-43

DO - 10.1186/1757-7241-17-43

M3 - Journal article

VL - 17

SP - 43

JO - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

JF - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

SN - 1757-7241

IS - 1

ER -