Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange

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Resumé

BACKGROUND: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.

METHODS: Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein.

RESULTS: While the hepatic vein contained higher levels of thromboxane B2 than the portal vein, levels of prostaglandin E2 and D2 were higher in the portal vein (all P<0.0001). Baseline concentrations of thromboxane B2 in the portal vein were independently associated with an increase of portal hepatic venous pressure gradient during short term follow-up, as an indirect sign of thrombogenic potential (multivariable P = 0.004). Moreover, severity of liver disease was inversely correlated with portal as well as hepatic vein levels of prostaglandin D2 and E2 (all P<0.0001).

CONCLUSIONS: Elevated portal venous thromboxane B2 concentrations are possibly associated with the extent of thrombogenic potential in patients with decompensated liver cirrhosis.

TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03584204.

OriginalsprogEngelsk
Artikelnummere0222840
TidsskriftPLOS ONE
Vol/bind14
Udgave nummer10
Antal sider12
ISSN1932-6203
DOI
StatusUdgivet - 23. okt. 2019

Fingeraftryk

liver cirrhosis
Portal Vein
Coagulation
coagulation
Liver Cirrhosis
Liver
prostaglandins
Prostaglandins
thromboxanes
portal vein
Prostaglandin D2
Thromboxane B2
Hepatic Veins
Dinoprostone
Transjugular Intrahepatic Portasystemic Shunt
liver
Portal Pressure
platelet aggregation
thrombosis
liver diseases

Citer dette

Queck, A., Thomas, D., Jansen, C., Schreiber, Y., Rüschenbaum, S., Praktiknjo, M., ... Lange, C. M. (2019). Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. PLOS ONE, 14(10), [e0222840]. https://doi.org/10.1371/journal.pone.0222840
Queck, Alexander ; Thomas, Dominique ; Jansen, Christian ; Schreiber, Yannick ; Rüschenbaum, Sabrina ; Praktiknjo, Michael ; Schwarzkopf, Katharina Maria ; Mücke, Marcus Maximilian ; Schierwagen, Robert ; Uschner, Frank Erhard ; Meyer, Carsten ; Clària, Joan ; Zeuzem, Stefan ; Geisslinger, Gerd ; Trebicka, Jonel ; Lange, Christian Markus. / Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. I: PLOS ONE. 2019 ; Bind 14, Nr. 10.
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title = "Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis",
abstract = "BACKGROUND: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.METHODS: Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein.RESULTS: While the hepatic vein contained higher levels of thromboxane B2 than the portal vein, levels of prostaglandin E2 and D2 were higher in the portal vein (all P<0.0001). Baseline concentrations of thromboxane B2 in the portal vein were independently associated with an increase of portal hepatic venous pressure gradient during short term follow-up, as an indirect sign of thrombogenic potential (multivariable P = 0.004). Moreover, severity of liver disease was inversely correlated with portal as well as hepatic vein levels of prostaglandin D2 and E2 (all P<0.0001).CONCLUSIONS: Elevated portal venous thromboxane B2 concentrations are possibly associated with the extent of thrombogenic potential in patients with decompensated liver cirrhosis.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03584204.",
author = "Alexander Queck and Dominique Thomas and Christian Jansen and Yannick Schreiber and Sabrina R{\"u}schenbaum and Michael Praktiknjo and Schwarzkopf, {Katharina Maria} and M{\"u}cke, {Marcus Maximilian} and Robert Schierwagen and Uschner, {Frank Erhard} and Carsten Meyer and Joan Cl{\`a}ria and Stefan Zeuzem and Gerd Geisslinger and Jonel Trebicka and Lange, {Christian Markus}",
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Queck, A, Thomas, D, Jansen, C, Schreiber, Y, Rüschenbaum, S, Praktiknjo, M, Schwarzkopf, KM, Mücke, MM, Schierwagen, R, Uschner, FE, Meyer, C, Clària, J, Zeuzem, S, Geisslinger, G, Trebicka, J & Lange, CM 2019, 'Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis', PLOS ONE, bind 14, nr. 10, e0222840. https://doi.org/10.1371/journal.pone.0222840

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. / Queck, Alexander; Thomas, Dominique; Jansen, Christian; Schreiber, Yannick; Rüschenbaum, Sabrina; Praktiknjo, Michael; Schwarzkopf, Katharina Maria; Mücke, Marcus Maximilian; Schierwagen, Robert; Uschner, Frank Erhard; Meyer, Carsten; Clària, Joan; Zeuzem, Stefan; Geisslinger, Gerd; Trebicka, Jonel; Lange, Christian Markus.

I: PLOS ONE, Bind 14, Nr. 10, e0222840, 23.10.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

AU - Queck, Alexander

AU - Thomas, Dominique

AU - Jansen, Christian

AU - Schreiber, Yannick

AU - Rüschenbaum, Sabrina

AU - Praktiknjo, Michael

AU - Schwarzkopf, Katharina Maria

AU - Mücke, Marcus Maximilian

AU - Schierwagen, Robert

AU - Uschner, Frank Erhard

AU - Meyer, Carsten

AU - Clària, Joan

AU - Zeuzem, Stefan

AU - Geisslinger, Gerd

AU - Trebicka, Jonel

AU - Lange, Christian Markus

PY - 2019/10/23

Y1 - 2019/10/23

N2 - BACKGROUND: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.METHODS: Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein.RESULTS: While the hepatic vein contained higher levels of thromboxane B2 than the portal vein, levels of prostaglandin E2 and D2 were higher in the portal vein (all P<0.0001). Baseline concentrations of thromboxane B2 in the portal vein were independently associated with an increase of portal hepatic venous pressure gradient during short term follow-up, as an indirect sign of thrombogenic potential (multivariable P = 0.004). Moreover, severity of liver disease was inversely correlated with portal as well as hepatic vein levels of prostaglandin D2 and E2 (all P<0.0001).CONCLUSIONS: Elevated portal venous thromboxane B2 concentrations are possibly associated with the extent of thrombogenic potential in patients with decompensated liver cirrhosis.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03584204.

AB - BACKGROUND: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.METHODS: Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein.RESULTS: While the hepatic vein contained higher levels of thromboxane B2 than the portal vein, levels of prostaglandin E2 and D2 were higher in the portal vein (all P<0.0001). Baseline concentrations of thromboxane B2 in the portal vein were independently associated with an increase of portal hepatic venous pressure gradient during short term follow-up, as an indirect sign of thrombogenic potential (multivariable P = 0.004). Moreover, severity of liver disease was inversely correlated with portal as well as hepatic vein levels of prostaglandin D2 and E2 (all P<0.0001).CONCLUSIONS: Elevated portal venous thromboxane B2 concentrations are possibly associated with the extent of thrombogenic potential in patients with decompensated liver cirrhosis.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03584204.

U2 - 10.1371/journal.pone.0222840

DO - 10.1371/journal.pone.0222840

M3 - Journal article

C2 - 31644538

VL - 14

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 10

M1 - e0222840

ER -

Queck A, Thomas D, Jansen C, Schreiber Y, Rüschenbaum S, Praktiknjo M et al. Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. PLOS ONE. 2019 okt 23;14(10). e0222840. https://doi.org/10.1371/journal.pone.0222840