Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG

B Gruvberger, Klaus Ejner Andersen, F M Brandão, D P Bruynzeel, M Bruze, P J Frosch, A Goossens, A Lahti, M Lindberg, T Menné, D Orton, S Seidenari

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2005-Jan
OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind52
Udgave nummer1
Sider (fra-til)14-8
ISSN0105-1873
DOI
StatusUdgivet - 2005

Fingeraftryk

Patch Tests
Multicenter Studies
Hypersensitivity
Irritants
Allergic Contact Dermatitis
Petrolatum

Citer dette

Gruvberger, B., Andersen, K. E., Brandão, F. M., Bruynzeel, D. P., Bruze, M., Frosch, P. J., ... Seidenari, S. (2005). Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG. Contact Dermatitis, 52(1), 14-8. https://doi.org/10.1111/j.0105-1873.2005.00480.x
Gruvberger, B ; Andersen, Klaus Ejner ; Brandão, F M ; Bruynzeel, D P ; Bruze, M ; Frosch, P J ; Goossens, A ; Lahti, A ; Lindberg, M ; Menné, T ; Orton, D ; Seidenari, S. / Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG. I: Contact Dermatitis. 2005 ; Bind 52, Nr. 1. s. 14-8.
@article{a6ea77e0ddd811db9628000ea68e967b,
title = "Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG",
abstract = "Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0{\%}, 0.5{\%}, 0.3{\%} and 0.1{\%} were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1{\%} following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5{\%} with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests.",
keywords = "Allergens, Cosmetics, Dermatitis, Allergic Contact, Europe, Female, Humans, Male, Nitriles, Patch Tests, Predictive Value of Tests, Preservatives, Pharmaceutical, Research Design",
author = "B Gruvberger and Andersen, {Klaus Ejner} and Brand{\~a}o, {F M} and Bruynzeel, {D P} and M Bruze and Frosch, {P J} and A Goossens and A Lahti and M Lindberg and T Menn{\'e} and D Orton and S Seidenari",
year = "2005",
doi = "10.1111/j.0105-1873.2005.00480.x",
language = "English",
volume = "52",
pages = "14--8",
journal = "Contact Dermatitis",
issn = "0105-1873",
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Gruvberger, B, Andersen, KE, Brandão, FM, Bruynzeel, DP, Bruze, M, Frosch, PJ, Goossens, A, Lahti, A, Lindberg, M, Menné, T, Orton, D & Seidenari, S 2005, 'Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG', Contact Dermatitis, bind 52, nr. 1, s. 14-8. https://doi.org/10.1111/j.0105-1873.2005.00480.x

Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG. / Gruvberger, B; Andersen, Klaus Ejner; Brandão, F M; Bruynzeel, D P; Bruze, M; Frosch, P J; Goossens, A; Lahti, A; Lindberg, M; Menné, T; Orton, D; Seidenari, S.

I: Contact Dermatitis, Bind 52, Nr. 1, 2005, s. 14-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG

AU - Gruvberger, B

AU - Andersen, Klaus Ejner

AU - Brandão, F M

AU - Bruynzeel, D P

AU - Bruze, M

AU - Frosch, P J

AU - Goossens, A

AU - Lahti, A

AU - Lindberg, M

AU - Menné, T

AU - Orton, D

AU - Seidenari, S

PY - 2005

Y1 - 2005

N2 - Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5% with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests.

AB - Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5% with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests.

KW - Allergens

KW - Cosmetics

KW - Dermatitis, Allergic Contact

KW - Europe

KW - Female

KW - Humans

KW - Male

KW - Nitriles

KW - Patch Tests

KW - Predictive Value of Tests

KW - Preservatives, Pharmaceutical

KW - Research Design

U2 - 10.1111/j.0105-1873.2005.00480.x

DO - 10.1111/j.0105-1873.2005.00480.x

M3 - Journal article

C2 - 15701124

VL - 52

SP - 14

EP - 18

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 1

ER -