Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy

Ann Pontén, Kristiina Aalto-Korte, Tove Agner, Klaus Ejner Andersen, Ana M Giménez-Arnau, Margarida Gonçalo, An Goossens, Jeanne Duus Johansen, Christophe J Le Coz, Howard I Maibach, Thomas Rustemeyer, Ian R White, Magnus Bruze

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Resumé

Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p <0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind68
Udgave nummer1
Sider (fra-til)50-53
Antal sider4
ISSN0105-1873
DOI
StatusUdgivet - 2012

Fingeraftryk

Formaldehyde
Hypersensitivity
Patch Tests
Dermatology
Sex Characteristics
Allergens
Multicenter Studies

Citer dette

Pontén, Ann ; Aalto-Korte, Kristiina ; Agner, Tove ; Andersen, Klaus Ejner ; Giménez-Arnau, Ana M ; Gonçalo, Margarida ; Goossens, An ; Johansen, Jeanne Duus ; Le Coz, Christophe J ; Maibach, Howard I ; Rustemeyer, Thomas ; White, Ian R ; Bruze, Magnus. / Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy. I: Contact Dermatitis. 2012 ; Bind 68, Nr. 1. s. 50-53.
@article{40358b02489642f6bd3ff0cd2e9b6f2b,
title = "Patch testing with 2.0{\%} (0.60 mg/cm(2) ) formaldehyde instead of 1.0{\%} (0.30 mg/cm(2) ) detects significantly more contact allergy",
abstract = "Background.The currently used patch test concentration for formaldehyde is 1.0{\%} (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0{\%} might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1{\%} (wt/vol) and 2{\%} (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0{\%} (wt/vol) (0.60 mg/cm(2) ) and 1.0{\%} (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0{\%} formaldehyde than to 1.0{\%} (3.4{\%} versus 1.8{\%}, p <0.001). Overall, there were no sex differences between those reacting positively to 2.0{\%} and 1.0{\%}. Of 25 quaternium-15-positive patients, 4 (0.1{\%}) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0{\%} (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.",
author = "Ann Pont{\'e}n and Kristiina Aalto-Korte and Tove Agner and Andersen, {Klaus Ejner} and Gim{\'e}nez-Arnau, {Ana M} and Margarida Gon{\cc}alo and An Goossens and Johansen, {Jeanne Duus} and {Le Coz}, {Christophe J} and Maibach, {Howard I} and Thomas Rustemeyer and White, {Ian R} and Magnus Bruze",
note = "{\circledC} 2012 John Wiley & Sons A/S.",
year = "2012",
doi = "10.1111/j.1600-0536.2012.02169.x",
language = "English",
volume = "68",
pages = "50--53",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "1",

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Pontén, A, Aalto-Korte, K, Agner, T, Andersen, KE, Giménez-Arnau, AM, Gonçalo, M, Goossens, A, Johansen, JD, Le Coz, CJ, Maibach, HI, Rustemeyer, T, White, IR & Bruze, M 2012, 'Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy', Contact Dermatitis, bind 68, nr. 1, s. 50-53. https://doi.org/10.1111/j.1600-0536.2012.02169.x

Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy. / Pontén, Ann; Aalto-Korte, Kristiina; Agner, Tove; Andersen, Klaus Ejner; Giménez-Arnau, Ana M; Gonçalo, Margarida; Goossens, An; Johansen, Jeanne Duus; Le Coz, Christophe J; Maibach, Howard I; Rustemeyer, Thomas; White, Ian R; Bruze, Magnus.

I: Contact Dermatitis, Bind 68, Nr. 1, 2012, s. 50-53.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy

AU - Pontén, Ann

AU - Aalto-Korte, Kristiina

AU - Agner, Tove

AU - Andersen, Klaus Ejner

AU - Giménez-Arnau, Ana M

AU - Gonçalo, Margarida

AU - Goossens, An

AU - Johansen, Jeanne Duus

AU - Le Coz, Christophe J

AU - Maibach, Howard I

AU - Rustemeyer, Thomas

AU - White, Ian R

AU - Bruze, Magnus

N1 - © 2012 John Wiley & Sons A/S.

PY - 2012

Y1 - 2012

N2 - Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p <0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.

AB - Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p <0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.

U2 - 10.1111/j.1600-0536.2012.02169.x

DO - 10.1111/j.1600-0536.2012.02169.x

M3 - Journal article

C2 - 23035891

VL - 68

SP - 50

EP - 53

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 1

ER -