Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

Helle Raun Andersen, Christine Wohlfahrt-Veje, Christine Dalgård, Lene Christiansen, Katharina Maria Main, Christine Lydia Nellemann, Katsuyuki Murata, Tina K Jensen, Niels Erik Skakkebæk, Philippe Grandjean

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Abstrakt

Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer5
Sider (fra-til)e36830
ISSN1932-6203
DOI
StatusUdgivet - 2012

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