Parallel RNA-strand recognition by 2'-amino-β-LNA

T. Santhosh Kumar, Michael E. Østergaard, Pawan K. Sharma, Poul Nielsen, Jesper Wengel, Patrick J. Hrdlicka

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.
OriginalsprogEngelsk
TidsskriftBioorganic & Medicinal Chemistry Letters
Vol/bind19
Udgave nummer9
Sider (fra-til)2396-2399
Antal sider4
ISSN0960-894X
DOI
StatusUdgivet - 2009

Fingeraftryk

Thymine
RNA
Complementary RNA
Nucleosides
Monomers
DNA
locked nucleic acid
phosphoramidite

Citer dette

Kumar, T. Santhosh ; Østergaard, Michael E. ; Sharma, Pawan K. ; Nielsen, Poul ; Wengel, Jesper ; Hrdlicka, Patrick J. / Parallel RNA-strand recognition by 2'-amino-β-LNA. I: Bioorganic & Medicinal Chemistry Letters. 2009 ; Bind 19, Nr. 9. s. 2396-2399.
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abstract = "A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.",
author = "Kumar, {T. Santhosh} and {\O}stergaard, {Michael E.} and Sharma, {Pawan K.} and Poul Nielsen and Jesper Wengel and Hrdlicka, {Patrick J.}",
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doi = "10.1016/j.bmcl.2009.03.079",
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Parallel RNA-strand recognition by 2'-amino-β-LNA. / Kumar, T. Santhosh; Østergaard, Michael E.; Sharma, Pawan K.; Nielsen, Poul; Wengel, Jesper; Hrdlicka, Patrick J.

I: Bioorganic & Medicinal Chemistry Letters, Bind 19, Nr. 9, 2009, s. 2396-2399.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Parallel RNA-strand recognition by 2'-amino-β-LNA

AU - Kumar, T. Santhosh

AU - Østergaard, Michael E.

AU - Sharma, Pawan K.

AU - Nielsen, Poul

AU - Wengel, Jesper

AU - Hrdlicka, Patrick J.

PY - 2009

Y1 - 2009

N2 - A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

AB - A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

U2 - 10.1016/j.bmcl.2009.03.079

DO - 10.1016/j.bmcl.2009.03.079

M3 - Journal article

VL - 19

SP - 2396

EP - 2399

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 9

ER -