Papillary thyroid carcinoma

correlations between prognosis, age, and clinicopathological and histomorphological findings

C Godballe, P Asschenfeldt, J A Sørensen, M W Sørensen, K Jørgensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The age influence on the prognosis of papillary thyroid carcinoma was analyzed in a group of 67 patients. A marked decline in cause-specific survival was found for patients older than 60 years of age at the time of diagnosis. In order to find a tumor-biological explanation of the prognostic difference between patients below and above 60 years of age, several clinicopathological and histomorphological features were analyzed. Tumors from patients older than 60 years of age showed significantly more mitotic activity and nuclear polymorphism, fewer psammoma bodies, and more frequent extrathyroidal invasion and distant metastases. The results indicate that 60 years of age the time of diagnosis may be the "prognostic break-point" for papillary thyroid carcinoma.

OriginalsprogEngelsk
TidsskriftLaryngoscope
Vol/bind104
Udgave nummer6 Pt 1
Sider (fra-til)747-51
Antal sider5
ISSN0023-852X
DOI
StatusUdgivet - jun. 1994

Fingeraftryk

Neoplasms

Citer dette

@article{7c6a15da83b248ee97f1499e92758896,
title = "Papillary thyroid carcinoma: correlations between prognosis, age, and clinicopathological and histomorphological findings",
abstract = "The age influence on the prognosis of papillary thyroid carcinoma was analyzed in a group of 67 patients. A marked decline in cause-specific survival was found for patients older than 60 years of age at the time of diagnosis. In order to find a tumor-biological explanation of the prognostic difference between patients below and above 60 years of age, several clinicopathological and histomorphological features were analyzed. Tumors from patients older than 60 years of age showed significantly more mitotic activity and nuclear polymorphism, fewer psammoma bodies, and more frequent extrathyroidal invasion and distant metastases. The results indicate that 60 years of age the time of diagnosis may be the {"}prognostic break-point{"} for papillary thyroid carcinoma.",
keywords = "Adult, Age Factors, Carcinoma, Papillary, Female, Humans, Male, Middle Aged, Prognosis, Survival Rate, Thyroid Neoplasms",
author = "C Godballe and P Asschenfeldt and S{\o}rensen, {J A} and S{\o}rensen, {M W} and K J{\o}rgensen",
year = "1994",
month = "6",
doi = "10.1288/00005537-199406000-00016",
language = "English",
volume = "104",
pages = "747--51",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "JohnWiley & Sons, Inc.",
number = "6 Pt 1",

}

Papillary thyroid carcinoma : correlations between prognosis, age, and clinicopathological and histomorphological findings. / Godballe, C; Asschenfeldt, P; Sørensen, J A; Sørensen, M W; Jørgensen, K.

I: Laryngoscope, Bind 104, Nr. 6 Pt 1, 06.1994, s. 747-51.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Papillary thyroid carcinoma

T2 - correlations between prognosis, age, and clinicopathological and histomorphological findings

AU - Godballe, C

AU - Asschenfeldt, P

AU - Sørensen, J A

AU - Sørensen, M W

AU - Jørgensen, K

PY - 1994/6

Y1 - 1994/6

N2 - The age influence on the prognosis of papillary thyroid carcinoma was analyzed in a group of 67 patients. A marked decline in cause-specific survival was found for patients older than 60 years of age at the time of diagnosis. In order to find a tumor-biological explanation of the prognostic difference between patients below and above 60 years of age, several clinicopathological and histomorphological features were analyzed. Tumors from patients older than 60 years of age showed significantly more mitotic activity and nuclear polymorphism, fewer psammoma bodies, and more frequent extrathyroidal invasion and distant metastases. The results indicate that 60 years of age the time of diagnosis may be the "prognostic break-point" for papillary thyroid carcinoma.

AB - The age influence on the prognosis of papillary thyroid carcinoma was analyzed in a group of 67 patients. A marked decline in cause-specific survival was found for patients older than 60 years of age at the time of diagnosis. In order to find a tumor-biological explanation of the prognostic difference between patients below and above 60 years of age, several clinicopathological and histomorphological features were analyzed. Tumors from patients older than 60 years of age showed significantly more mitotic activity and nuclear polymorphism, fewer psammoma bodies, and more frequent extrathyroidal invasion and distant metastases. The results indicate that 60 years of age the time of diagnosis may be the "prognostic break-point" for papillary thyroid carcinoma.

KW - Adult

KW - Age Factors

KW - Carcinoma, Papillary

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Survival Rate

KW - Thyroid Neoplasms

U2 - 10.1288/00005537-199406000-00016

DO - 10.1288/00005537-199406000-00016

M3 - Journal article

VL - 104

SP - 747

EP - 751

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 6 Pt 1

ER -