P-GP INDUCERS AS PROTECTORS AGAINST CHEMOTHERAPY-INDUCED SIDE EFFECTS, SUCH AS PERIPHERAL NEUROPATHY (CIPN) AND HAIR LOSS

Tore Stage (Opfinder)

Publikation: Patent

Abstrakt

The present invention relates to compositions comprising a P-gp inducer, for topical use in preventing one or more side effects of chemotherapeutics, which chemotherapeutics are transported out of cells by P-gp. Especially chemotherapy-induced peripheral neuropathy (CIPN) is a relevant side effect to treat/avoid, since CIPN may be a dose limiting side effect of chemotherapy. The invention also relates to kits and to cancer treatment of a subgroup of patients, which subgroup has been topically pretreated with a P-gp inducer.

OriginalsprogEngelsk
IPCA61P 43/ 00 A I
PatentnummerWO2021043673
Journaliseringsdato28/08/2020
Land/OmrådeDanmark
Prioritetsdato02/09/2019
PrioritetsnummerEP20190194881
StatusUdgivet - 11. mar. 2021

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