Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Morten Thorsen; Niels Bilenberg; Lena Thorsen; Tanja Maria Michel

doi:10.1007/s10803-021-04897-x

Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Morten Thorsen^*, Niels Bilenberg, Lena Thorsen, Tanja Maria Michel

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Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.

Originalsprog	Engelsk
Tidsskrift	Journal of Autism and Developmental Disorders
Vol/bind	52
Udgave nummer	1
Sider (fra-til)	275-282
ISSN	0162-3257
DOI	https://doi.org/10.1007/s10803-021-04897-x
Status	Udgivet - jan. 2022

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10.1007/s10803-021-04897-x

Citationsformater

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abstract = "Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.",

keywords = "Autism Spectrum Disorder, Oxidative Stress, Sex, Superoxide Dismutase, Xanthine Oxidase, Autistic Disorder, Humans, Male, Case-Control Studies, Antioxidants/metabolism, Adult, Female, Child",

author = "Morten Thorsen and Niels Bilenberg and Lena Thorsen and Michel, {Tanja Maria}",

year = "2022",

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doi = "10.1007/s10803-021-04897-x",

language = "English",

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journal = "Journal of Autism and Developmental Disorders",

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TY - JOUR

T1 - Oxidative Stress in Adults with Autism Spectrum Disorder

T2 - A Case Control Study

AU - Thorsen, Morten

AU - Bilenberg, Niels

AU - Thorsen, Lena

AU - Michel, Tanja Maria

PY - 2022/1

Y1 - 2022/1

N2 - Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.

AB - Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.

KW - Autism Spectrum Disorder

KW - Oxidative Stress

KW - Sex

KW - Superoxide Dismutase

KW - Xanthine Oxidase

KW - Autistic Disorder

KW - Humans

KW - Male

KW - Case-Control Studies

KW - Antioxidants/metabolism

KW - Adult

KW - Female

KW - Child

U2 - 10.1007/s10803-021-04897-x

DO - 10.1007/s10803-021-04897-x

M3 - Journal article

C2 - 33677727

SN - 0162-3257

VL - 52

SP - 275

EP - 282

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 1

ER -

Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Abstract

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