Overexpression of vimentin in canine prostatic carcinoma

M M P Rodrigues, A Rema, F Gärtner, F A Soares, S R Rogatto, V M B D De Mour, R Laufer-Amorim

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Canine prostatic tumours exhibit similarities to those of man and may represent a useful model system to explore the mechanisms of cancer progression. Tumour progression to malignancy requires a change from an epithelial phenotype to a fibroblastic or mesenchymal phenotype. Vimentin expression is associated with the invasive phenotype of human prostate cancer cells. The aim of the present study was to characterize immunohistochemically the expression of vimentin by canine prostatic carcinomas. Primary carcinomas and metastatic tumour foci both showed vimentin expression. This finding suggests that the acquisition of the epithelial-mesenchymal transition phenotype in canine prostatic carcinoma may be characterized by the presence of mesenchymal intermediate filament (vimentin) that could lead to a higher likelihood of metastasis.

OriginalsprogEngelsk
TidsskriftJournal of Comparative Pathology
Vol/bind144
Udgave nummer4
Sider (fra-til)308-11
Antal sider4
ISSN0021-9975
DOI
StatusUdgivet - 2011

Fingeraftryk

vimentin
Vimentin
carcinoma
phenotype
dogs
prostatic neoplasms
neoplasms
Neoplasms
intermediate filaments
metastasis
Intermediate Filaments
Prostatic Neoplasms

Citer dette

Rodrigues, M. M. P., Rema, A., Gärtner, F., Soares, F. A., Rogatto, S. R., De Mour, V. M. B. D., & Laufer-Amorim, R. (2011). Overexpression of vimentin in canine prostatic carcinoma. Journal of Comparative Pathology, 144(4), 308-11. https://doi.org/10.1016/j.jcpa.2010.08.016
Rodrigues, M M P ; Rema, A ; Gärtner, F ; Soares, F A ; Rogatto, S R ; De Mour, V M B D ; Laufer-Amorim, R. / Overexpression of vimentin in canine prostatic carcinoma. I: Journal of Comparative Pathology. 2011 ; Bind 144, Nr. 4. s. 308-11.
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abstract = "Canine prostatic tumours exhibit similarities to those of man and may represent a useful model system to explore the mechanisms of cancer progression. Tumour progression to malignancy requires a change from an epithelial phenotype to a fibroblastic or mesenchymal phenotype. Vimentin expression is associated with the invasive phenotype of human prostate cancer cells. The aim of the present study was to characterize immunohistochemically the expression of vimentin by canine prostatic carcinomas. Primary carcinomas and metastatic tumour foci both showed vimentin expression. This finding suggests that the acquisition of the epithelial-mesenchymal transition phenotype in canine prostatic carcinoma may be characterized by the presence of mesenchymal intermediate filament (vimentin) that could lead to a higher likelihood of metastasis.",
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Rodrigues, MMP, Rema, A, Gärtner, F, Soares, FA, Rogatto, SR, De Mour, VMBD & Laufer-Amorim, R 2011, 'Overexpression of vimentin in canine prostatic carcinoma', Journal of Comparative Pathology, bind 144, nr. 4, s. 308-11. https://doi.org/10.1016/j.jcpa.2010.08.016

Overexpression of vimentin in canine prostatic carcinoma. / Rodrigues, M M P; Rema, A; Gärtner, F; Soares, F A; Rogatto, S R; De Mour, V M B D; Laufer-Amorim, R.

I: Journal of Comparative Pathology, Bind 144, Nr. 4, 2011, s. 308-11.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Overexpression of vimentin in canine prostatic carcinoma

AU - Rodrigues, M M P

AU - Rema, A

AU - Gärtner, F

AU - Soares, F A

AU - Rogatto, S R

AU - De Mour, V M B D

AU - Laufer-Amorim, R

N1 - Published by Elsevier Ltd.

PY - 2011

Y1 - 2011

N2 - Canine prostatic tumours exhibit similarities to those of man and may represent a useful model system to explore the mechanisms of cancer progression. Tumour progression to malignancy requires a change from an epithelial phenotype to a fibroblastic or mesenchymal phenotype. Vimentin expression is associated with the invasive phenotype of human prostate cancer cells. The aim of the present study was to characterize immunohistochemically the expression of vimentin by canine prostatic carcinomas. Primary carcinomas and metastatic tumour foci both showed vimentin expression. This finding suggests that the acquisition of the epithelial-mesenchymal transition phenotype in canine prostatic carcinoma may be characterized by the presence of mesenchymal intermediate filament (vimentin) that could lead to a higher likelihood of metastasis.

AB - Canine prostatic tumours exhibit similarities to those of man and may represent a useful model system to explore the mechanisms of cancer progression. Tumour progression to malignancy requires a change from an epithelial phenotype to a fibroblastic or mesenchymal phenotype. Vimentin expression is associated with the invasive phenotype of human prostate cancer cells. The aim of the present study was to characterize immunohistochemically the expression of vimentin by canine prostatic carcinomas. Primary carcinomas and metastatic tumour foci both showed vimentin expression. This finding suggests that the acquisition of the epithelial-mesenchymal transition phenotype in canine prostatic carcinoma may be characterized by the presence of mesenchymal intermediate filament (vimentin) that could lead to a higher likelihood of metastasis.

KW - Adenocarcinoma

KW - Animals

KW - Biomarkers, Tumor

KW - Dog Diseases

KW - Dogs

KW - Immunohistochemistry

KW - Male

KW - Prostate

KW - Prostatic Neoplasms

KW - Tissue Array Analysis

KW - Vimentin

U2 - 10.1016/j.jcpa.2010.08.016

DO - 10.1016/j.jcpa.2010.08.016

M3 - Journal article

C2 - 20961558

VL - 144

SP - 308

EP - 311

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

SN - 0021-9975

IS - 4

ER -