Outcomes after revascularisation with everolimus- and sirolimus-eluting stents in patients with acute coronary syndromes and stable angina pectoris: a substudy of the SORT OUT IV trial

Lisbeth Antonsen, Per Thayssen, Henrik S Hansen, Michael Maeng, Hans-Henrik Tilsted, Hans E Bøtker, Jan Ravkilde, Morten Madsen, Henrik T Sørensen, Leif Thuesen, Jens F Lassen, Lisette O Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Aims: The aim of this substudy of the SORT OUT IV trial was to compare clinical outcomes among patients with acute coronary syndromes (ACS) and stable angina pectoris (SAP) treated with everolimus-eluting stents (EES) or sirolimus-eluting stents (SES). Methods and results: We performed a post hoc subgroup analysis of data from SORT OUT IV. Of 2,705 patients, 1,178 (43.5%) patients had ACS and were treated with EES (n=580) or SES (n=598), and 1,527 (56.5%) patients had SAP and were treated with EES (n=773) or SES (n=754). The primary composite endpoint was major adverse cardiac events (MACE): cardiac death, myocardial infarction (MI), stent thrombosis, or target vessel revascularisation within 18 months. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for the endpoints. At 18-month follow-up, patients with ACS had higher rates of MACE compared to patients with SAP (8.1% versus 6.7%; HR=1.23, 95% CI: 0.93-1.62). MACE did not differ significantly between ACS patients treated with EES or SES (7.3% versus 8.9%; HR=0.81, 95% CI: 0.54-1.22) nor between SAP patients treated with EES or SES (6.9% versus 6.5%; HR=1.05, 95% CI: 0.71-1.55). Conclusions: EES and SES performed similarly with respect to MACE at 18-month follow-up in patients with ACS and SAP.

OriginalsprogEngelsk
TidsskriftEuroIntervention
Vol/bind10
Udgave nummer2
Sider (fra-til)212-223
ISSN1774-024X
DOI
StatusUdgivet - 2014

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