Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute: an experimental study in dogs

T B Jensen, S Overgaard, M Lind, O Rahbek, Cody Bünger, Kjeld Søballe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Impacted bone allograft is often used in revision joint replacement. Hydroxyapatite granules have been suggested as a substitute or to enhance morcellised bone allograft. We hypothesised that adding osteogenic protein-1 to a composite of bone allograft and non-resorbable hydroxyapatite granules (ProOsteon) would improve the incorporation of bone and implant fixation. We also compared the response to using ProOsteon alone against bone allograft used in isolation. We implanted two non-weight-bearing hydroxyapatite-coated implants into each proximal humerus of six dogs, with each implant surrounded by a concentric 3 mm gap. These gaps were randomly allocated to four different procedures in each dog: 1) bone allograft used on its own; 2) ProOsteon used on its own; 3) allograft and ProOsteon used together; or 4) allograft and ProOsteon with the addition of osteogenic protein-1. After three weeks osteogenic protein-1 increased bone formation and the energy absorption of implants grafted with allograft and ProOsteon. A composite of allograft, ProOsteon and osteogenic protein-1 was comparable, but not superior to, allograft used on its own. ProOsteon alone cannot be recommended as a substitute for allograft around non-cemented implants, but should be used to extend the volume of the graft, preferably with the addition of a growth factor.
OriginalsprogEngelsk
TidsskriftJournal of Bone and Joint Surgery, British Volume
Vol/bind89
Udgave nummer1
Sider (fra-til)121-6
Antal sider6
ISSN2049-4394
DOI
StatusUdgivet - 1. jan. 2007

Fingeraftryk

Bone Substitutes
Allografts
Dogs
Durapatite
Osteogenesis

Citer dette

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abstract = "Impacted bone allograft is often used in revision joint replacement. Hydroxyapatite granules have been suggested as a substitute or to enhance morcellised bone allograft. We hypothesised that adding osteogenic protein-1 to a composite of bone allograft and non-resorbable hydroxyapatite granules (ProOsteon) would improve the incorporation of bone and implant fixation. We also compared the response to using ProOsteon alone against bone allograft used in isolation. We implanted two non-weight-bearing hydroxyapatite-coated implants into each proximal humerus of six dogs, with each implant surrounded by a concentric 3 mm gap. These gaps were randomly allocated to four different procedures in each dog: 1) bone allograft used on its own; 2) ProOsteon used on its own; 3) allograft and ProOsteon used together; or 4) allograft and ProOsteon with the addition of osteogenic protein-1. After three weeks osteogenic protein-1 increased bone formation and the energy absorption of implants grafted with allograft and ProOsteon. A composite of allograft, ProOsteon and osteogenic protein-1 was comparable, but not superior to, allograft used on its own. ProOsteon alone cannot be recommended as a substitute for allograft around non-cemented implants, but should be used to extend the volume of the graft, preferably with the addition of a growth factor.",
keywords = "Animals, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins, Bone Substitutes, Bone Transplantation, Coated Materials, Biocompatible, Dogs, Drug Evaluation, Preclinical, Durapatite, Joint Prosthesis, Osseointegration, Osteogenesis, Random Allocation, Transforming Growth Factor beta",
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Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute: an experimental study in dogs. / Jensen, T B; Overgaard, S; Lind, M; Rahbek, O; Bünger, Cody; Søballe, Kjeld.

I: Journal of Bone and Joint Surgery, British Volume, Bind 89, Nr. 1, 01.01.2007, s. 121-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute: an experimental study in dogs

AU - Jensen, T B

AU - Overgaard, S

AU - Lind, M

AU - Rahbek, O

AU - Bünger, Cody

AU - Søballe, Kjeld

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Impacted bone allograft is often used in revision joint replacement. Hydroxyapatite granules have been suggested as a substitute or to enhance morcellised bone allograft. We hypothesised that adding osteogenic protein-1 to a composite of bone allograft and non-resorbable hydroxyapatite granules (ProOsteon) would improve the incorporation of bone and implant fixation. We also compared the response to using ProOsteon alone against bone allograft used in isolation. We implanted two non-weight-bearing hydroxyapatite-coated implants into each proximal humerus of six dogs, with each implant surrounded by a concentric 3 mm gap. These gaps were randomly allocated to four different procedures in each dog: 1) bone allograft used on its own; 2) ProOsteon used on its own; 3) allograft and ProOsteon used together; or 4) allograft and ProOsteon with the addition of osteogenic protein-1. After three weeks osteogenic protein-1 increased bone formation and the energy absorption of implants grafted with allograft and ProOsteon. A composite of allograft, ProOsteon and osteogenic protein-1 was comparable, but not superior to, allograft used on its own. ProOsteon alone cannot be recommended as a substitute for allograft around non-cemented implants, but should be used to extend the volume of the graft, preferably with the addition of a growth factor.

AB - Impacted bone allograft is often used in revision joint replacement. Hydroxyapatite granules have been suggested as a substitute or to enhance morcellised bone allograft. We hypothesised that adding osteogenic protein-1 to a composite of bone allograft and non-resorbable hydroxyapatite granules (ProOsteon) would improve the incorporation of bone and implant fixation. We also compared the response to using ProOsteon alone against bone allograft used in isolation. We implanted two non-weight-bearing hydroxyapatite-coated implants into each proximal humerus of six dogs, with each implant surrounded by a concentric 3 mm gap. These gaps were randomly allocated to four different procedures in each dog: 1) bone allograft used on its own; 2) ProOsteon used on its own; 3) allograft and ProOsteon used together; or 4) allograft and ProOsteon with the addition of osteogenic protein-1. After three weeks osteogenic protein-1 increased bone formation and the energy absorption of implants grafted with allograft and ProOsteon. A composite of allograft, ProOsteon and osteogenic protein-1 was comparable, but not superior to, allograft used on its own. ProOsteon alone cannot be recommended as a substitute for allograft around non-cemented implants, but should be used to extend the volume of the graft, preferably with the addition of a growth factor.

KW - Animals

KW - Bone Morphogenetic Protein 7

KW - Bone Morphogenetic Proteins

KW - Bone Substitutes

KW - Bone Transplantation

KW - Coated Materials, Biocompatible

KW - Dogs

KW - Drug Evaluation, Preclinical

KW - Durapatite

KW - Joint Prosthesis

KW - Osseointegration

KW - Osteogenesis

KW - Random Allocation

KW - Transforming Growth Factor beta

U2 - 10.1302/0301-620X.89B1.17077

DO - 10.1302/0301-620X.89B1.17077

M3 - Journal article

VL - 89

SP - 121

EP - 126

JO - Journal of Bone and Joint Surgery, British Volume

JF - Journal of Bone and Joint Surgery, British Volume

SN - 2049-4394

IS - 1

ER -