Osteogenic protein 1 device stimulates bone healing to hydroxyapaptite-coated and titanium implants

M Lind, S Overgaard, Y Song, S B Goodman, C Bünger, K Søballe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

This study evaluated the effects of osteogenic protein 1 (OP-1) placed in a gap around uncoated and hydroxyapatite (HA)-coated implants. Unloaded cylindrical titanium alloy implants were inserted in the femoral condyles of 16 skeletally mature dogs surrounded by a 3-mm gap. The gap around the implants was filled with 325 microg OP-1 in 130 mg bovine collagen type I as carrier (OP-1 device) or collagen carrier alone or left empty. All groups were tested with both HA-coated and uncoated implants, and the animals were sacrificed after 6 weeks. Implant fixation was determined by push-out test. Bone ongrowth and bone formation were evaluated by quantitative histomorphometry. OP-1 device enhanced mechanical fixation of uncoated and HA-coated implants, resulting in a higher shear strength than implants with collagen matrix and control implants. Bone ingrowth and bone formation in the gap were also stimulated 3-fold for OP-1 groups when compared with empty controls, but no difference was found between OP-1 groups and collagen matrix groups. This study suggests that the OP-1 device placed in a gap around uncoated and HA-coated implants is capable of enhancing mechanical fixation and periimplant bone formation. The collagen carrier alone also enhanced bone ongrowth and fixation significantly.

OriginalsprogEngelsk
TidsskriftThe Journal of arthroplasty
Vol/bind15
Udgave nummer3
Sider (fra-til)339-46
Antal sider8
ISSN0883-5403
StatusUdgivet - apr. 2000

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