Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Pierre J Marie; Moustapha Kassem

doi:10.1530/EJE-11-0132

Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstrakt

Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	165
Udgave nummer	1
Sider (fra-til)	1-10
Antal sider	10
ISSN	0804-4643
DOI	https://doi.org/10.1530/EJE-11-0132
Status	Udgivet - 2011

Dokumenter og links

10.1530/EJE-11-0132

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Citationsformater

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abstract = "Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.",

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AU - Kassem, Moustapha

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AB - Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.

KW - Aging

KW - Anabolic Agents

KW - Animals

KW - Bone Morphogenetic Proteins

KW - Bone Resorption

KW - Female

KW - Genetic Markers

KW - Growth Hormone

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Insulin-Like Growth Factor I

KW - Osteoblasts

KW - Osteogenesis

KW - Osteoporosis

KW - Parathyroid Hormone

KW - Receptors, Calcium-Sensing

KW - Signal Transduction

KW - Transforming Growth Factor beta1

KW - Wnt Proteins

KW - beta Catenin

U2 - 10.1530/EJE-11-0132

DO - 10.1530/EJE-11-0132

M3 - Journal article

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VL - 165

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EP - 10

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

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