Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Pierre J Marie, Moustapha Kassem

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Abstrakt

Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind165
Udgave nummer1
Sider (fra-til)1-10
Antal sider10
ISSN0804-4643
DOI
StatusUdgivet - 2011

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