Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Pierre J Marie, Moustapha Kassem

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind165
Udgave nummer1
Sider (fra-til)1-10
Antal sider10
ISSN0804-4643
DOI
StatusUdgivet - 2011

Fingeraftryk

Osteoblasts
Osteogenesis
Pharmaceutical Preparations

Citer dette

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Osteoblasts in osteoporosis: past, emerging, and future anabolic targets. / Marie, Pierre J; Kassem, Moustapha.

I: European Journal of Endocrinology, Bind 165, Nr. 1, 2011, s. 1-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Kassem, Moustapha

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KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

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KW - Osteoporosis

KW - Parathyroid Hormone

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KW - Signal Transduction

KW - Transforming Growth Factor beta1

KW - Wnt Proteins

KW - beta Catenin

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