Resumé
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Endocrinology |
| Vol/bind | 165 |
| Udgave nummer | 1 |
| Sider (fra-til) | 1-10 |
| Antal sider | 10 |
| ISSN | 0804-4643 |
| DOI | |
| Status | Udgivet - 2011 |
Fingeraftryk
Citer dette
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Osteoblasts in osteoporosis: past, emerging, and future anabolic targets. / Marie, Pierre J; Kassem, Moustapha.
I: European Journal of Endocrinology, Bind 165, Nr. 1, 2011, s. 1-10.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Osteoblasts in osteoporosis: past, emerging, and future anabolic targets
AU - Marie, Pierre J
AU - Kassem, Moustapha
PY - 2011
Y1 - 2011
N2 - Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.
AB - Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.
KW - Aging
KW - Anabolic Agents
KW - Animals
KW - Bone Morphogenetic Proteins
KW - Bone Resorption
KW - Female
KW - Genetic Markers
KW - Growth Hormone
KW - Humans
KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW - Insulin-Like Growth Factor I
KW - Osteoblasts
KW - Osteogenesis
KW - Osteoporosis
KW - Parathyroid Hormone
KW - Receptors, Calcium-Sensing
KW - Signal Transduction
KW - Transforming Growth Factor beta1
KW - Wnt Proteins
KW - beta Catenin
U2 - 10.1530/EJE-11-0132
DO - 10.1530/EJE-11-0132
M3 - Journal article
C2 - 21543379
VL - 165
SP - 1
EP - 10
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -