Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes

Stine Byberg*, Dorte Vistisen, Lars Diaz, Morten H. Charles, Javad Nouri Hajari, Marianne Valerius, Ellen Juul, Marit E. Jørgensen, Henrik Lund-Andersen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Purpose: Diabetic retinopathy (DR) screening methods are costly, requiring specialized personnel and patient mydriasis. The Optos apparatus can be operated by nonspecialists and provides ultra-wide-field imaging, with 200° views of the retina in a single image. We compared DR grading obtained from Optos imaging with DR grading from conventional Topcon imaging. Methods: We conducted a cross-sectional study of 101 persons with diabetes who participated in the Addition-DK 10-year follow-up study. Retina fundus photos using both Optos and Topcon imaging were taken for both eyes. All photos were graded by specialist ophthalmologic nurses, using a modified version of the ‘Proposed International Clinical DR severity scale’. We constructed frequency tables and assessed levels of agreement between Optos and Topcon gradings using weighted Kappa statistics, separately for peripheral and macular grading. We tested if the agreements between the two cameras were significantly different using a stratified Wilcoxon test. Results: Significantly, more lesions in the periphery were identified by Optos compared with Topcon (p < 0.01), resulting in a fair Kappa agreement of 0.21. We saw no significant differences in the grading of the macula region (p = 0.97) between the two cameras. Although only 7% of the macula image gradings differed between the cameras, the Kappa agreement of macula grading was only moderate (Kappa = 0.52). Conclusion: The inter-camera agreement was acceptable for macula image grading, but only fair for peripheral grading, with Optos identifying more microvascular changes in the periphery. The clinical significance and impact on screening modality and frequency remain to be explored.

OriginalsprogEngelsk
TidsskriftActa Ophthalmologica
ISSN1755-375X
DOI
StatusUdgivet - 2019

Fingeraftryk

Diabetic Retinopathy
Type 2 Diabetes Mellitus
Retina
Mydriasis
Cross-Sectional Studies

Citer dette

Byberg, S., Vistisen, D., Diaz, L., Charles, M. H., Hajari, J. N., Valerius, M., ... Lund-Andersen, H. (2019). Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes. Acta Ophthalmologica. https://doi.org/10.1111/aos.14118
Byberg, Stine ; Vistisen, Dorte ; Diaz, Lars ; Charles, Morten H. ; Hajari, Javad Nouri ; Valerius, Marianne ; Juul, Ellen ; Jørgensen, Marit E. ; Lund-Andersen, Henrik. / Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes. I: Acta Ophthalmologica. 2019.
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abstract = "Purpose: Diabetic retinopathy (DR) screening methods are costly, requiring specialized personnel and patient mydriasis. The Optos apparatus can be operated by nonspecialists and provides ultra-wide-field imaging, with 200° views of the retina in a single image. We compared DR grading obtained from Optos imaging with DR grading from conventional Topcon imaging. Methods: We conducted a cross-sectional study of 101 persons with diabetes who participated in the Addition-DK 10-year follow-up study. Retina fundus photos using both Optos and Topcon imaging were taken for both eyes. All photos were graded by specialist ophthalmologic nurses, using a modified version of the ‘Proposed International Clinical DR severity scale’. We constructed frequency tables and assessed levels of agreement between Optos and Topcon gradings using weighted Kappa statistics, separately for peripheral and macular grading. We tested if the agreements between the two cameras were significantly different using a stratified Wilcoxon test. Results: Significantly, more lesions in the periphery were identified by Optos compared with Topcon (p < 0.01), resulting in a fair Kappa agreement of 0.21. We saw no significant differences in the grading of the macula region (p = 0.97) between the two cameras. Although only 7{\%} of the macula image gradings differed between the cameras, the Kappa agreement of macula grading was only moderate (Kappa = 0.52). Conclusion: The inter-camera agreement was acceptable for macula image grading, but only fair for peripheral grading, with Optos identifying more microvascular changes in the periphery. The clinical significance and impact on screening modality and frequency remain to be explored.",
keywords = "diabetic retinopathy, screening, ultra-wide-field, validation",
author = "Stine Byberg and Dorte Vistisen and Lars Diaz and Charles, {Morten H.} and Hajari, {Javad Nouri} and Marianne Valerius and Ellen Juul and J{\o}rgensen, {Marit E.} and Henrik Lund-Andersen",
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doi = "10.1111/aos.14118",
language = "English",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
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Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes. / Byberg, Stine; Vistisen, Dorte; Diaz, Lars; Charles, Morten H.; Hajari, Javad Nouri; Valerius, Marianne; Juul, Ellen; Jørgensen, Marit E.; Lund-Andersen, Henrik.

I: Acta Ophthalmologica, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes

AU - Byberg, Stine

AU - Vistisen, Dorte

AU - Diaz, Lars

AU - Charles, Morten H.

AU - Hajari, Javad Nouri

AU - Valerius, Marianne

AU - Juul, Ellen

AU - Jørgensen, Marit E.

AU - Lund-Andersen, Henrik

PY - 2019

Y1 - 2019

N2 - Purpose: Diabetic retinopathy (DR) screening methods are costly, requiring specialized personnel and patient mydriasis. The Optos apparatus can be operated by nonspecialists and provides ultra-wide-field imaging, with 200° views of the retina in a single image. We compared DR grading obtained from Optos imaging with DR grading from conventional Topcon imaging. Methods: We conducted a cross-sectional study of 101 persons with diabetes who participated in the Addition-DK 10-year follow-up study. Retina fundus photos using both Optos and Topcon imaging were taken for both eyes. All photos were graded by specialist ophthalmologic nurses, using a modified version of the ‘Proposed International Clinical DR severity scale’. We constructed frequency tables and assessed levels of agreement between Optos and Topcon gradings using weighted Kappa statistics, separately for peripheral and macular grading. We tested if the agreements between the two cameras were significantly different using a stratified Wilcoxon test. Results: Significantly, more lesions in the periphery were identified by Optos compared with Topcon (p < 0.01), resulting in a fair Kappa agreement of 0.21. We saw no significant differences in the grading of the macula region (p = 0.97) between the two cameras. Although only 7% of the macula image gradings differed between the cameras, the Kappa agreement of macula grading was only moderate (Kappa = 0.52). Conclusion: The inter-camera agreement was acceptable for macula image grading, but only fair for peripheral grading, with Optos identifying more microvascular changes in the periphery. The clinical significance and impact on screening modality and frequency remain to be explored.

AB - Purpose: Diabetic retinopathy (DR) screening methods are costly, requiring specialized personnel and patient mydriasis. The Optos apparatus can be operated by nonspecialists and provides ultra-wide-field imaging, with 200° views of the retina in a single image. We compared DR grading obtained from Optos imaging with DR grading from conventional Topcon imaging. Methods: We conducted a cross-sectional study of 101 persons with diabetes who participated in the Addition-DK 10-year follow-up study. Retina fundus photos using both Optos and Topcon imaging were taken for both eyes. All photos were graded by specialist ophthalmologic nurses, using a modified version of the ‘Proposed International Clinical DR severity scale’. We constructed frequency tables and assessed levels of agreement between Optos and Topcon gradings using weighted Kappa statistics, separately for peripheral and macular grading. We tested if the agreements between the two cameras were significantly different using a stratified Wilcoxon test. Results: Significantly, more lesions in the periphery were identified by Optos compared with Topcon (p < 0.01), resulting in a fair Kappa agreement of 0.21. We saw no significant differences in the grading of the macula region (p = 0.97) between the two cameras. Although only 7% of the macula image gradings differed between the cameras, the Kappa agreement of macula grading was only moderate (Kappa = 0.52). Conclusion: The inter-camera agreement was acceptable for macula image grading, but only fair for peripheral grading, with Optos identifying more microvascular changes in the periphery. The clinical significance and impact on screening modality and frequency remain to be explored.

KW - diabetic retinopathy

KW - screening

KW - ultra-wide-field

KW - validation

U2 - 10.1111/aos.14118

DO - 10.1111/aos.14118

M3 - Journal article

C2 - 30985086

AN - SCOPUS:85064518466

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

ER -