Background: Stenting-induced edge dissections (ED) can be assessed in detail by optical coherence tomography (OCT). This study sought to investigate the incidence, morphological characteristics, and spontaneous healing course of OCT-identified EDs following drug-eluting stent (DES) implantation in a non-ST segment elevation myocardial infarction (NSTEMI) patient-population. Methods: Acute vessel wall injury at the 5-mm stent adjacent distal and proximal reference segments was assessed by post-procedure OCT and intravascular ultrasound (IVUS) in n = 97 NSTEMI-patients (n = 97 lesions). Six months OCT follow-up was available in 82 patients (including 35 untreated post-procedure EDs). Results: The overall incidence of post-procedure OCT-detected ED was 38 per 97 patients (39.2%), and 47 per 182 stent edges (25.8%). None of the EDs were angiographically visualizable, while 10 (21.3%) were visible on concomitant IVUS-analysis. Morphologically, there was a significant difference in plaque type present at ED-edges vs. non-ED-edges when assessed with OCT; (1) lipid-rich and calcified plaques: 80.9% vs. 57.0%, (2) fibrous plaques: 17.0% vs. 26.7%, and (3) normal coronary vessels: 2.1% vs. 16.3%, p < 0.01. Plaqueburden, assessed by IVUS, was substantially larger at ED-containing borders: 54.5 +/- 10.0% vs. 43.7 +/- 11.6%, p = 0.01. Three dissections (8.6%) were incompletely healed at 6-month OCT follow-up. None of the EDs caused cardiac events during the 6-month follow-up, however, 1 ED-patient had target lesion revascularization with PCI and DES-implantation in extension of the scheduled OCT-control. Conclusions: OCT-detected EDs were frequent after stent implantation due to NSTEMI, and the majority of these EDs healed without leading to an adverse prognosis at 6 months. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Bibliografisk noteISI Document Delivery No.: EB0LV Times Cited: 0 Cited Reference Count: 30 Antonsen, Lisbeth Thayssen, Per Hansen, Henrik Steen Junker, Anders Veien, Karsten Tange Hansen, Knud Norregaard Hougaard, Mikkel Jensen, Lisette Okkels Danish Heart Foundation The Danish Heart Foundation supported this study. 0 3 Elsevier ireland ltd Clare 1874-1754
Antonsen, L., Thayssen, P., Hansen, H. S., Junker, A., Veien, K. T., Hansen, K. N., Hougaard, M., & Jensen, L. O. (2016). Optical coherence tomography assessment of incidence, morphological characteristics, and spontaneous healing course of edge dissections following percutaneous coronary intervention with stent implantation in patients with non-ST segment elevation myocardial infarction. International Journal of Cardiology, 223, 466-474. https://doi.org/10.1016/j.ijcard.2016.08.245