On-chip immunomagnetic separation of bacteria by in-flow dynamic manipulation of paramagnetic beads

Shakil Ahmed, Jong Wook Noh, James Hoyland, Roana Melina de Oliveira Hansen, Helmut Erdmann, Horst-Günter Rubahn

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Every year, millions of people all over the world fall ill due to the consumption of unsafe food, where consumption of contaminated and spoiled animal origin product is the main cause for diseases due to bacterial growth. This leads to an intense need for efficient methods for detection of food-related bacteria. In this work, we present a method for integration of immunomagnetic separation of bacteria into microfluidic technology by applying an alternating magnetic field, which manipulates the paramagnetic beads into a sinusoidal path across the whole microchannel, increasing the probability for bacteria capture. The optimum channel geometry, flow rate and alternating magnetic field frequency were investigated, resulting in a capture efficiency of 68 %.

OriginalsprogEngelsk
Artikelnummer955
TidsskriftApplied Physics A
Vol/bind122
Udgave nummer11
ISSN0947-8396
DOI
StatusUdgivet - nov. 2016

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