TY - JOUR
T1 - OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis
AU - Gossec, Laure
AU - Hawker, Gillian
AU - Davis, Aileen M
AU - Maillefert, Jean Francis
AU - Lohmander, L Stefan
AU - Altman, Roy
AU - Cibere, Jolanda
AU - Conaghan, Philip G
AU - Hochberg, Marc C
AU - Jordan, Joanne M
AU - Katz, Jeffrey N
AU - March, Lyn
AU - Mahomed, Nizar
AU - Pavelka, Karel
AU - Roos, Ewa
AU - Suarez-Almazor, Maria E
AU - Zanoli, Gustavo
AU - Dougados, Maxime
PY - 2007/6/1
Y1 - 2007/6/1
N2 - OBJECTIVE: Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." METHODS: For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. RESULTS: For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. CONCLUSION: Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.
AB - OBJECTIVE: Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." METHODS: For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. RESULTS: For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. CONCLUSION: Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.
KW - Arthroplasty, Replacement, Hip
KW - Arthroplasty, Replacement, Knee
KW - Disability Evaluation
KW - Disease Progression
KW - Focus Groups
KW - Humans
KW - International Cooperation
KW - Interviews as Topic
KW - Osteoarthritis, Hip
KW - Osteoarthritis, Knee
KW - Outcome Assessment (Health Care)
KW - Pain Measurement
KW - Reproducibility of Results
KW - Severity of Illness Index
M3 - Journal article
C2 - 17552070
SN - 0315-162X
VL - 34
SP - 1432
EP - 1435
JO - The Journal of Rheumatology
JF - The Journal of Rheumatology
IS - 6
ER -