Occurrence and prognostic relevance of CD30 expression in post-transplant lymphoproliferative disorders

M. Ø. Vase, E. F. Maksten, K. Bendix, S. Hamilton-Dutoit, C. Andersen, M. B. Moller, S. S. Sorensen, B. Jespersen, J. Kampmann, E. Sondergard, Patricia Switten Nielsen, F. D'Amore

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Abstrakt

Post-transplant lymphoproliferative disorders (PTLDs) are potentiallyfatal, often Epstein-Barr virus (EBV)-driven neoplasias developing in immunocompromised hosts. Initial treatment usually consists of a reduction in immunosuppressive therapy and/or rituximab with or without chemotherapy. However, patients who relapse do poorly, and new treatment options are warranted. With the introduction of the immunoconjugate brentuximab vedotin, the CD30 antigen has become an effectively targetable molecule. Therefore, we investigated the frequency and level of CD30 expression in PTLDs. We identified 108 patients with PTLDs diagnosed during 1994-2011, of whom 62 had adequate paraffin-embedded tissue for tissue microarray construction. Immunohistochemical expression of CD30 was consistently detected in all types of PTLD (overall 85.25%), including the monomorphic subtypes, and was correlated with a more favorable outcome. For diffuse large B-cell lymphoma (DLBCL)-type PTLD this was regardless of EBV status, and remained significant in multivariate analysis. Cell-of-origin had no independent prognostic value in our series of DLBCL PTLD.
OriginalsprogEngelsk
TidsskriftLeukemia and Lymphoma
Vol/bind56
Udgave nummer6
Sider (fra-til)1677-1685
ISSN1042-8194
DOI
StatusUdgivet - 2015

Bibliografisk note

Aarhus University; Karen Elise Jensen Foundation; Foundation of Eva and Henry Frankel, Grosserer M. Brogaard and Wife Memorial Foundation; Danish Cancer Society; Einar Willumsens Memorial Foundation; Manager Jacob Madsen and wife Olga Madsen's Foundation 1 25248878

Emneord

  • CD30 PTLD EBV cell-of-origin EPSTEIN-BARR-VIRUS B-CELL LYMPHOMA HODGKINS-LYMPHOMA BRENTUXIMAB VEDOTIN SOLUBLE CD30 INFECTION SURVIVAL MARKER IMPACT TISSUE

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