Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature

Lene Snabe Nielsen, Jesper Bælum, Jesper Rasmussen, Søren Dahl, Karen Ege Olsen, Maria Albin, Niels-Christian Gerner Hansen, David Lee Sherson

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The objective of this study was to evaluate the scientific literature concerning asbestos and lung cancer, emphasizing low-level exposure. A literature search in PubMed and Embase resulted in 5,864 citations. Information from included studies was extracted using SIGN. Twenty-one statements were evidence graded. The results show that histology and location are not helpful in differentiating asbestos-related lung cancer. Pleural plaques, asbestos bodies, or asbestos fibers are useful as markers of asbestos exposure. The interaction between asbestos and smoking regarding lung cancer risk is between additive and multiplicative. The findings indicate that the association between asbestos exposure and lung cancer risk is basically linear, but may level off at very high exposures. The relative risk for lung cancer increases between 1% and 4% per fiber-year (f-y)/mL, corresponding to a doubling of risk at 25-100 f-y/mL. However, one high-quality case-control study showed a doubling at 4 f-y/mL.

OriginalsprogEngelsk
TidsskriftArchives of Environmental and Occupational Health
Vol/bind69
Udgave nummer4
Sider (fra-til)191-206
Antal sider16
ISSN1933-8244
DOI
StatusUdgivet - 2014

Fingeraftryk

Asbestos
asbestos
Occupational Exposure
Lung
cancer
Fibers
Literature
Histology
histology
exposure
smoking
PubMed
quality control
Case-Control Studies
Smoking
fibre

Citer dette

@article{b820a6e1da74496fb6a9bf96aa6ef919,
title = "Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature",
abstract = "The objective of this study was to evaluate the scientific literature concerning asbestos and lung cancer, emphasizing low-level exposure. A literature search in PubMed and Embase resulted in 5,864 citations. Information from included studies was extracted using SIGN. Twenty-one statements were evidence graded. The results show that histology and location are not helpful in differentiating asbestos-related lung cancer. Pleural plaques, asbestos bodies, or asbestos fibers are useful as markers of asbestos exposure. The interaction between asbestos and smoking regarding lung cancer risk is between additive and multiplicative. The findings indicate that the association between asbestos exposure and lung cancer risk is basically linear, but may level off at very high exposures. The relative risk for lung cancer increases between 1{\%} and 4{\%} per fiber-year (f-y)/mL, corresponding to a doubling of risk at 25-100 f-y/mL. However, one high-quality case-control study showed a doubling at 4 f-y/mL.",
author = "Nielsen, {Lene Snabe} and Jesper B{\ae}lum and Jesper Rasmussen and S{\o}ren Dahl and Olsen, {Karen Ege} and Maria Albin and {Gerner Hansen}, Niels-Christian and {Lee Sherson}, David",
year = "2014",
doi = "10.1080/19338244.2013.863752",
language = "English",
volume = "69",
pages = "191--206",
journal = "Archives of Environmental and Occupational Health",
issn = "1933-8244",
publisher = "Taylor & Francis",
number = "4",

}

Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature. / Nielsen, Lene Snabe; Bælum, Jesper; Rasmussen, Jesper; Dahl, Søren; Olsen, Karen Ege; Albin, Maria; Gerner Hansen, Niels-Christian ; Lee Sherson, David.

I: Archives of Environmental and Occupational Health, Bind 69, Nr. 4, 2014, s. 191-206.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature

AU - Nielsen, Lene Snabe

AU - Bælum, Jesper

AU - Rasmussen, Jesper

AU - Dahl, Søren

AU - Olsen, Karen Ege

AU - Albin, Maria

AU - Gerner Hansen, Niels-Christian

AU - Lee Sherson, David

PY - 2014

Y1 - 2014

N2 - The objective of this study was to evaluate the scientific literature concerning asbestos and lung cancer, emphasizing low-level exposure. A literature search in PubMed and Embase resulted in 5,864 citations. Information from included studies was extracted using SIGN. Twenty-one statements were evidence graded. The results show that histology and location are not helpful in differentiating asbestos-related lung cancer. Pleural plaques, asbestos bodies, or asbestos fibers are useful as markers of asbestos exposure. The interaction between asbestos and smoking regarding lung cancer risk is between additive and multiplicative. The findings indicate that the association between asbestos exposure and lung cancer risk is basically linear, but may level off at very high exposures. The relative risk for lung cancer increases between 1% and 4% per fiber-year (f-y)/mL, corresponding to a doubling of risk at 25-100 f-y/mL. However, one high-quality case-control study showed a doubling at 4 f-y/mL.

AB - The objective of this study was to evaluate the scientific literature concerning asbestos and lung cancer, emphasizing low-level exposure. A literature search in PubMed and Embase resulted in 5,864 citations. Information from included studies was extracted using SIGN. Twenty-one statements were evidence graded. The results show that histology and location are not helpful in differentiating asbestos-related lung cancer. Pleural plaques, asbestos bodies, or asbestos fibers are useful as markers of asbestos exposure. The interaction between asbestos and smoking regarding lung cancer risk is between additive and multiplicative. The findings indicate that the association between asbestos exposure and lung cancer risk is basically linear, but may level off at very high exposures. The relative risk for lung cancer increases between 1% and 4% per fiber-year (f-y)/mL, corresponding to a doubling of risk at 25-100 f-y/mL. However, one high-quality case-control study showed a doubling at 4 f-y/mL.

U2 - 10.1080/19338244.2013.863752

DO - 10.1080/19338244.2013.863752

M3 - Journal article

VL - 69

SP - 191

EP - 206

JO - Archives of Environmental and Occupational Health

JF - Archives of Environmental and Occupational Health

SN - 1933-8244

IS - 4

ER -