Observed and predicted reduction of ischemic cardiovascular events in the Simvastatin and Ezetimibe in Aortic Stenosis trial

Ingar Holme, Kurt Boman, Philippe Brudi, Kenneth Egstrup, Christa Gohlke-Baerwolf, Y Antero Kesäniemi, William Malbecq, Anne B Rossebø, Kristian Wachtell, Ronnie Willenheimer, Terje R Pedersen

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Abstrakt

In the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) trial, combined ezetimibe (10 mg) and simvastatin (40 mg) decreased low-density lipoprotein cholesterol levels by 50% and ischemic cardiovascular event (ICE) risk by 22% compared to placebo. A larger decrease in ICE risk might have been expected for the degree of lipid-lowering observed. This analysis investigated relations between changes in lipoprotein components (LCs), and ICE risk decrease in the SEAS trial in all patients, by severity of aortic stenosis (AS), and compared to results of other clinical trials. A total of 1,570 patients with baseline aortic jet velocity (JV) data, baseline and 1-year low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoprotein B, and no ICEs during the first year were included in the analysis. Relations between on-treatment measurements of 1-year LCs and time-to-ICE occurrence were assessed in all patients and in JV tertiles (3.3 m/s). Observed and predicted ICE risk decreases were compared by Cox model. Decreases in LCs after 1 year of ezetimibe plus simvastatin were associated with decreased ICE risk in all patients and in the 2 lower JV tertiles (p
OriginalsprogEngelsk
TidsskriftAmerican Journal of Cardiology
Vol/bind105
Udgave nummer12
Sider (fra-til)1802-8
Antal sider7
ISSN0002-9149
DOI
StatusUdgivet - 15. jun. 2010

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Holme, I., Boman, K., Brudi, P., Egstrup, K., Gohlke-Baerwolf, C., Kesäniemi, Y. A., Malbecq, W., Rossebø, A. B., Wachtell, K., Willenheimer, R., & Pedersen, T. R. (2010). Observed and predicted reduction of ischemic cardiovascular events in the Simvastatin and Ezetimibe in Aortic Stenosis trial. American Journal of Cardiology, 105(12), 1802-8. https://doi.org/10.1016/j.amjcard.2010.01.363