Obesity

lessons from evolution and the environment

B L Heitmann, K R Westerterp, R J F Loos, T I A Sørensen, K O'Dea, P McLean, Tina Kold Jensen, J Eisenmann, J R Speakman, S J Simpson, D R Reed, M S Westerterp-Plantenga

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The 9th Stock Conference acknowledged the complex background of genetic, cultural, environmental and evolutionary factors of obesity. Gene-environment interactions underlie the flexibility in body-weight and body-fat regulation, illustrated by the hunter-gatherers' feast and famine lifestyle, the variation in physical activity over the lifespan being highest at reproductive age, the variation in energy intake through 'eating in the absence of hunger', while running the risk of exceeding the capacity of triacylglyceride storage, leading to lipotoxicity and metabolic problems. Perinatal metabolic programming for obesity via epigenetic changes in response to a 'Western diet' results in production of lipid-poor milk and metabolically efficient pups, contributing to the perpetuation of obesity throughout generations. Evolutionary insight from comparative physiology and ecology indicates that over generations activity-induced energy expenditure has remained the same compared to wild mammals, that energy balance might be dependant on protein balance, while the function of taste changed from detection of poison or energy to social drinking and social behaviour. At present, the impact of assortative mating on obesity prevalence is unambiguously positive. The complexity that appeared can only be fully appreciated by setting the data into the context of our evolutionary history.
OriginalsprogEngelsk
TidsskriftObesity Reviews
Vol/bind13
Udgave nummer10
Sider (fra-til)910-22
Antal sider13
ISSN1467-7881
DOI
StatusUdgivet - 2012

Fingeraftryk

Comparative Physiology
Drinking Behavior
Gene-Environment Interaction
Poisons
Ecology
Epigenomics
Energy Metabolism
Adipose Tissue
Mammals
History
Lipids
Proteins
Genetic Background
Western Diet

Citer dette

Heitmann, B. L., Westerterp, K. R., Loos, R. J. F., Sørensen, T. I. A., O'Dea, K., McLean, P., ... Westerterp-Plantenga, M. S. (2012). Obesity: lessons from evolution and the environment. Obesity Reviews, 13(10), 910-22. https://doi.org/10.1111/j.1467-789X.2012.01007.x
Heitmann, B L ; Westerterp, K R ; Loos, R J F ; Sørensen, T I A ; O'Dea, K ; McLean, P ; Jensen, Tina Kold ; Eisenmann, J ; Speakman, J R ; Simpson, S J ; Reed, D R ; Westerterp-Plantenga, M S. / Obesity : lessons from evolution and the environment. I: Obesity Reviews. 2012 ; Bind 13, Nr. 10. s. 910-22.
@article{f38a6f2346cf4c629c9b2b0226e0beeb,
title = "Obesity: lessons from evolution and the environment",
abstract = "The 9th Stock Conference acknowledged the complex background of genetic, cultural, environmental and evolutionary factors of obesity. Gene-environment interactions underlie the flexibility in body-weight and body-fat regulation, illustrated by the hunter-gatherers' feast and famine lifestyle, the variation in physical activity over the lifespan being highest at reproductive age, the variation in energy intake through 'eating in the absence of hunger', while running the risk of exceeding the capacity of triacylglyceride storage, leading to lipotoxicity and metabolic problems. Perinatal metabolic programming for obesity via epigenetic changes in response to a 'Western diet' results in production of lipid-poor milk and metabolically efficient pups, contributing to the perpetuation of obesity throughout generations. Evolutionary insight from comparative physiology and ecology indicates that over generations activity-induced energy expenditure has remained the same compared to wild mammals, that energy balance might be dependant on protein balance, while the function of taste changed from detection of poison or energy to social drinking and social behaviour. At present, the impact of assortative mating on obesity prevalence is unambiguously positive. The complexity that appeared can only be fully appreciated by setting the data into the context of our evolutionary history.",
keywords = "Biological Evolution, Congresses as Topic, Diet, Energy Metabolism, Gene-Environment Interaction, Humans, Life Style, Obesity, Social Behavior",
author = "Heitmann, {B L} and Westerterp, {K R} and Loos, {R J F} and S{\o}rensen, {T I A} and K O'Dea and P McLean and Jensen, {Tina Kold} and J Eisenmann and Speakman, {J R} and Simpson, {S J} and Reed, {D R} and Westerterp-Plantenga, {M S}",
note = "{\circledC} 2012 The Authors. obesity reviews {\circledC} 2012 International Association for the Study of Obesity.",
year = "2012",
doi = "10.1111/j.1467-789X.2012.01007.x",
language = "English",
volume = "13",
pages = "910--22",
journal = "Obesity Reviews",
issn = "1467-7881",
publisher = "Wiley-Blackwell",
number = "10",

}

Heitmann, BL, Westerterp, KR, Loos, RJF, Sørensen, TIA, O'Dea, K, McLean, P, Jensen, TK, Eisenmann, J, Speakman, JR, Simpson, SJ, Reed, DR & Westerterp-Plantenga, MS 2012, 'Obesity: lessons from evolution and the environment', Obesity Reviews, bind 13, nr. 10, s. 910-22. https://doi.org/10.1111/j.1467-789X.2012.01007.x

Obesity : lessons from evolution and the environment. / Heitmann, B L; Westerterp, K R; Loos, R J F; Sørensen, T I A; O'Dea, K; McLean, P; Jensen, Tina Kold; Eisenmann, J; Speakman, J R; Simpson, S J; Reed, D R; Westerterp-Plantenga, M S.

I: Obesity Reviews, Bind 13, Nr. 10, 2012, s. 910-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Obesity

T2 - lessons from evolution and the environment

AU - Heitmann, B L

AU - Westerterp, K R

AU - Loos, R J F

AU - Sørensen, T I A

AU - O'Dea, K

AU - McLean, P

AU - Jensen, Tina Kold

AU - Eisenmann, J

AU - Speakman, J R

AU - Simpson, S J

AU - Reed, D R

AU - Westerterp-Plantenga, M S

N1 - © 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.

PY - 2012

Y1 - 2012

N2 - The 9th Stock Conference acknowledged the complex background of genetic, cultural, environmental and evolutionary factors of obesity. Gene-environment interactions underlie the flexibility in body-weight and body-fat regulation, illustrated by the hunter-gatherers' feast and famine lifestyle, the variation in physical activity over the lifespan being highest at reproductive age, the variation in energy intake through 'eating in the absence of hunger', while running the risk of exceeding the capacity of triacylglyceride storage, leading to lipotoxicity and metabolic problems. Perinatal metabolic programming for obesity via epigenetic changes in response to a 'Western diet' results in production of lipid-poor milk and metabolically efficient pups, contributing to the perpetuation of obesity throughout generations. Evolutionary insight from comparative physiology and ecology indicates that over generations activity-induced energy expenditure has remained the same compared to wild mammals, that energy balance might be dependant on protein balance, while the function of taste changed from detection of poison or energy to social drinking and social behaviour. At present, the impact of assortative mating on obesity prevalence is unambiguously positive. The complexity that appeared can only be fully appreciated by setting the data into the context of our evolutionary history.

AB - The 9th Stock Conference acknowledged the complex background of genetic, cultural, environmental and evolutionary factors of obesity. Gene-environment interactions underlie the flexibility in body-weight and body-fat regulation, illustrated by the hunter-gatherers' feast and famine lifestyle, the variation in physical activity over the lifespan being highest at reproductive age, the variation in energy intake through 'eating in the absence of hunger', while running the risk of exceeding the capacity of triacylglyceride storage, leading to lipotoxicity and metabolic problems. Perinatal metabolic programming for obesity via epigenetic changes in response to a 'Western diet' results in production of lipid-poor milk and metabolically efficient pups, contributing to the perpetuation of obesity throughout generations. Evolutionary insight from comparative physiology and ecology indicates that over generations activity-induced energy expenditure has remained the same compared to wild mammals, that energy balance might be dependant on protein balance, while the function of taste changed from detection of poison or energy to social drinking and social behaviour. At present, the impact of assortative mating on obesity prevalence is unambiguously positive. The complexity that appeared can only be fully appreciated by setting the data into the context of our evolutionary history.

KW - Biological Evolution

KW - Congresses as Topic

KW - Diet

KW - Energy Metabolism

KW - Gene-Environment Interaction

KW - Humans

KW - Life Style

KW - Obesity

KW - Social Behavior

U2 - 10.1111/j.1467-789X.2012.01007.x

DO - 10.1111/j.1467-789X.2012.01007.x

M3 - Journal article

VL - 13

SP - 910

EP - 922

JO - Obesity Reviews

JF - Obesity Reviews

SN - 1467-7881

IS - 10

ER -

Heitmann BL, Westerterp KR, Loos RJF, Sørensen TIA, O'Dea K, McLean P et al. Obesity: lessons from evolution and the environment. Obesity Reviews. 2012;13(10):910-22. https://doi.org/10.1111/j.1467-789X.2012.01007.x