Nuclear thyroid hormone receptor binding in human mononuclear blood cells after goitre resection

J Kvetny, L E Matzen, M Blichert-Toft, S Watt-Boolsen, J Date

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1989-Mar
OriginalsprogEngelsk
TidsskriftHormone and Metabolic Research
Vol/bind21
Udgave nummer3
Sider (fra-til)142-4
Antal sider2
ISSN0018-5043
DOI
StatusUdgivet - 1989

Fingeraftryk

Thyroid Hormone Receptors
Cytoplasmic and Nuclear Receptors
Blood
Cells
Serum

Citer dette

Kvetny, J ; Matzen, L E ; Blichert-Toft, M ; Watt-Boolsen, S ; Date, J. / Nuclear thyroid hormone receptor binding in human mononuclear blood cells after goitre resection. I: Hormone and Metabolic Research. 1989 ; Bind 21, Nr. 3. s. 142-4.
@article{aa0f4a307bb511df846a000ea68e967b,
title = "Nuclear thyroid hormone receptor binding in human mononuclear blood cells after goitre resection",
abstract = "Nuclear thyroxine and triiodothyronine receptor-binding in human mononuclear blood cells were examined in 14 euthyroid persons prior to and 1, 6, 24 and 53 weeks after goitre resection. One week after resection decreased serum T3 from 1.47 nmol/l to 1.14 nmol/l (P less than 0.05), FT4I from 103 a. u. to 94 a. u. and SHBG from 80 nmol/l to 69 nmol/l (P less than 0.05) followed after 6 weeks by a rise in serum TSH from 1.2 mU/l to 11.0 mU/l (P less than 0.05) suggesting an initial slight hypothyroidism. Nuclear receptor-binding of T4 and T3 increased within one week and eventually decreased to preresectional values. We conclude that the expected alteration of the metabolic state caused by resection of the gland is opposed by increased nuclear binding of T4 and T3.",
keywords = "Adult, Cell Nucleus, Goiter, Humans, Iodine Radioisotopes, Middle Aged, Monocytes, Receptors, Thyroid Hormone, Thyroxine, Time Factors, Triiodothyronine",
author = "J Kvetny and Matzen, {L E} and M Blichert-Toft and S Watt-Boolsen and J Date",
year = "1989",
doi = "10.1055/s-2007-1009174",
language = "English",
volume = "21",
pages = "142--4",
journal = "Hormone and Metabolic Research",
issn = "0018-5043",
publisher = "GeorgThieme Verlag",
number = "3",

}

Nuclear thyroid hormone receptor binding in human mononuclear blood cells after goitre resection. / Kvetny, J; Matzen, L E; Blichert-Toft, M; Watt-Boolsen, S; Date, J.

I: Hormone and Metabolic Research, Bind 21, Nr. 3, 1989, s. 142-4.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Nuclear thyroid hormone receptor binding in human mononuclear blood cells after goitre resection

AU - Kvetny, J

AU - Matzen, L E

AU - Blichert-Toft, M

AU - Watt-Boolsen, S

AU - Date, J

PY - 1989

Y1 - 1989

N2 - Nuclear thyroxine and triiodothyronine receptor-binding in human mononuclear blood cells were examined in 14 euthyroid persons prior to and 1, 6, 24 and 53 weeks after goitre resection. One week after resection decreased serum T3 from 1.47 nmol/l to 1.14 nmol/l (P less than 0.05), FT4I from 103 a. u. to 94 a. u. and SHBG from 80 nmol/l to 69 nmol/l (P less than 0.05) followed after 6 weeks by a rise in serum TSH from 1.2 mU/l to 11.0 mU/l (P less than 0.05) suggesting an initial slight hypothyroidism. Nuclear receptor-binding of T4 and T3 increased within one week and eventually decreased to preresectional values. We conclude that the expected alteration of the metabolic state caused by resection of the gland is opposed by increased nuclear binding of T4 and T3.

AB - Nuclear thyroxine and triiodothyronine receptor-binding in human mononuclear blood cells were examined in 14 euthyroid persons prior to and 1, 6, 24 and 53 weeks after goitre resection. One week after resection decreased serum T3 from 1.47 nmol/l to 1.14 nmol/l (P less than 0.05), FT4I from 103 a. u. to 94 a. u. and SHBG from 80 nmol/l to 69 nmol/l (P less than 0.05) followed after 6 weeks by a rise in serum TSH from 1.2 mU/l to 11.0 mU/l (P less than 0.05) suggesting an initial slight hypothyroidism. Nuclear receptor-binding of T4 and T3 increased within one week and eventually decreased to preresectional values. We conclude that the expected alteration of the metabolic state caused by resection of the gland is opposed by increased nuclear binding of T4 and T3.

KW - Adult

KW - Cell Nucleus

KW - Goiter

KW - Humans

KW - Iodine Radioisotopes

KW - Middle Aged

KW - Monocytes

KW - Receptors, Thyroid Hormone

KW - Thyroxine

KW - Time Factors

KW - Triiodothyronine

U2 - 10.1055/s-2007-1009174

DO - 10.1055/s-2007-1009174

M3 - Journal article

VL - 21

SP - 142

EP - 144

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

SN - 0018-5043

IS - 3

ER -