Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a hospital laboratory (n = 107). NT-proBNP was measured on-site on Cobas h 232 instruments both in primary health care centres and at the hospital laboratory and all samples were also analyzed with a comparison method at the hospital. Precision, trueness, accuracy, and lot-variation were determined at different concentration levels and evaluated according to acceptance criteria. Furthermore user-friendliness was assessed by questionnaires. Results. For Cobas h 232 repeatability CV was 8.5-10.7% in the hospital setting and 5.3-10.0% in the primary health care and within the analytical quality specifications, but higher than with the comparison method (
Roche 0 26305423
- Natriuretic peptide biological markers heart disease point-of-care systems validation studies BRAIN NATRIURETIC PEPTIDE HEART-FAILURE PATIENTS BIOLOGICAL VARIATION ASSAY BNP DIAGNOSIS SYSTEM IMPACT PHASE AGE
, Ramanathan, R., Breindahl, T., Brokner, M., Lindegaard Christiansen, A.
, Eng, Ø., Hammer, I. J., Herrera, C. B., Jansen, A., Langsjoen, E. C., Løkkebo, E. S., Osestad, T., Schroder, A. D., & Walther, L. (2015). NT-proBNP on Cobas h 232 in point-of-care testing: Performance in the primary health care versus in the hospital laboratory
. Scandinavian Journal of Clinical & Laboratory Investigation
(7), 602-609. https://doi.org/10.3109/00365513.2015.1066846