Novel wound models for characterizing ibuprofen release from foam dressings

Bente Steffansen, Sofie P K Herping

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The purpose of the present study was to design and characterize low exudate level wound (LEW) and high exudate level wound (HEW) in vitro models by means of investigating therapeutic substance release from exudate-absorbing formulations. Biatain Ibu foam dressing was used to characterize in vitro release of ibuprofen within the models and also for in vitro-in vivo correlation (IVIVC) studies. Ibuprofen release was described by zero order rate constants of 0.0147 for 1 day and 0.0038 mg/cm(2) h for 3 days in HEW and LEW models, respectively. The release is suggested to be controlled by ibuprofen diffusion from the dressing in the HEW model, whereas fluid absorption is rate-limiting in the LEW model. Ibuprofen release, from Biatain Ibu foam dressings in vivo, is within the same ranges as in vitro. Thus, it is suggested that, depending on the level of exudate, the in vivo release of ibuprofen depends on ibuprofen diffusion from and absorption of exudates to the dressings. Consequently, both the HEW and LEW in vitro models should be applied in order to fully characterize ibuprofen release from Biatain Ibu foam dressings. Future studies may show whether these in vitro models can be used to characterize therapeutic substance release from exudate-absorbing formulations in general.

OriginalsprogEngelsk
TidsskriftInternational Journal of Pharmaceutics
Vol/bind364
Udgave nummer1
Sider (fra-til)150-5
Antal sider6
ISSN0378-5173
DOI
StatusUdgivet - 19. nov. 2008

Fingeraftryk

Ibuprofen
Exudates and Transudates
Wounds and Injuries
In Vitro Techniques

Citer dette

Steffansen, Bente ; Herping, Sofie P K. / Novel wound models for characterizing ibuprofen release from foam dressings. I: International Journal of Pharmaceutics. 2008 ; Bind 364, Nr. 1. s. 150-5.
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Novel wound models for characterizing ibuprofen release from foam dressings. / Steffansen, Bente; Herping, Sofie P K.

I: International Journal of Pharmaceutics, Bind 364, Nr. 1, 19.11.2008, s. 150-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Novel wound models for characterizing ibuprofen release from foam dressings

AU - Steffansen, Bente

AU - Herping, Sofie P K

PY - 2008/11/19

Y1 - 2008/11/19

N2 - The purpose of the present study was to design and characterize low exudate level wound (LEW) and high exudate level wound (HEW) in vitro models by means of investigating therapeutic substance release from exudate-absorbing formulations. Biatain Ibu foam dressing was used to characterize in vitro release of ibuprofen within the models and also for in vitro-in vivo correlation (IVIVC) studies. Ibuprofen release was described by zero order rate constants of 0.0147 for 1 day and 0.0038 mg/cm(2) h for 3 days in HEW and LEW models, respectively. The release is suggested to be controlled by ibuprofen diffusion from the dressing in the HEW model, whereas fluid absorption is rate-limiting in the LEW model. Ibuprofen release, from Biatain Ibu foam dressings in vivo, is within the same ranges as in vitro. Thus, it is suggested that, depending on the level of exudate, the in vivo release of ibuprofen depends on ibuprofen diffusion from and absorption of exudates to the dressings. Consequently, both the HEW and LEW in vitro models should be applied in order to fully characterize ibuprofen release from Biatain Ibu foam dressings. Future studies may show whether these in vitro models can be used to characterize therapeutic substance release from exudate-absorbing formulations in general.

AB - The purpose of the present study was to design and characterize low exudate level wound (LEW) and high exudate level wound (HEW) in vitro models by means of investigating therapeutic substance release from exudate-absorbing formulations. Biatain Ibu foam dressing was used to characterize in vitro release of ibuprofen within the models and also for in vitro-in vivo correlation (IVIVC) studies. Ibuprofen release was described by zero order rate constants of 0.0147 for 1 day and 0.0038 mg/cm(2) h for 3 days in HEW and LEW models, respectively. The release is suggested to be controlled by ibuprofen diffusion from the dressing in the HEW model, whereas fluid absorption is rate-limiting in the LEW model. Ibuprofen release, from Biatain Ibu foam dressings in vivo, is within the same ranges as in vitro. Thus, it is suggested that, depending on the level of exudate, the in vivo release of ibuprofen depends on ibuprofen diffusion from and absorption of exudates to the dressings. Consequently, both the HEW and LEW in vitro models should be applied in order to fully characterize ibuprofen release from Biatain Ibu foam dressings. Future studies may show whether these in vitro models can be used to characterize therapeutic substance release from exudate-absorbing formulations in general.

KW - Agar

KW - Algorithms

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Chromatography, High Pressure Liquid

KW - Data Interpretation, Statistical

KW - Diffusion

KW - Diffusion Chambers, Culture

KW - Exudates and Transudates

KW - Humans

KW - Ibuprofen

KW - Models, Biological

KW - Occlusive Dressings

KW - Polyurethanes

KW - Porosity

KW - Wound Healing

U2 - 10.1016/j.ijpharm.2008.07.025

DO - 10.1016/j.ijpharm.2008.07.025

M3 - Journal article

C2 - 18722518

VL - 364

SP - 150

EP - 155

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -