Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (Aryl S-DABOs)

Youssef L. Aly, Erik Bjerreg. Pedersen, Paolo La Colla, Roberta Loddo

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The synthesis and the anti-HIV-1 activity of a series of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs) are reported. These compounds were synthesized via a coupling reaction of the corresponding 6-benzyl-2-thiouracils with aryl iodides in the presence of neocuproine hydrate, copper(I) iodide, and sodium tert-butoxide. Target compounds showed moderate activity against HIV-1.
OriginalsprogEngelsk
TidsskriftSynthesis
Vol/bind13
Sider (fra-til)1955-1960
Antal sider6
ISSN0256-7245
DOI
StatusUdgivet - 2007

Fingeraftryk

Iodides
Hydrates
Sodium
neocuproine
cuprous iodide
benzylthiouracil

Citer dette

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title = "Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (Aryl S-DABOs)",
abstract = "The synthesis and the anti-HIV-1 activity of a series of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs) are reported. These compounds were synthesized via a coupling reaction of the corresponding 6-benzyl-2-thiouracils with aryl iodides in the presence of neocuproine hydrate, copper(I) iodide, and sodium tert-butoxide. Target compounds showed moderate activity against HIV-1.",
keywords = "medicinal chemistry; antiviral agents; HIV - non-nucleosides; S-DABO",
author = "Aly, {Youssef L.} and Pedersen, {Erik Bjerreg.} and {La Colla}, Paolo and Roberta Loddo",
year = "2007",
doi = "10.1055/s-2007-983732",
language = "English",
volume = "13",
pages = "1955--1960",
journal = "Synthesis",
issn = "0256-7245",
publisher = "Editura Academiei Rom{\^a}ne",

}

Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (Aryl S-DABOs). / Aly, Youssef L.; Pedersen, Erik Bjerreg.; La Colla, Paolo; Loddo, Roberta.

I: Synthesis, Bind 13, 2007, s. 1955-1960.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (Aryl S-DABOs)

AU - Aly, Youssef L.

AU - Pedersen, Erik Bjerreg.

AU - La Colla, Paolo

AU - Loddo, Roberta

PY - 2007

Y1 - 2007

N2 - The synthesis and the anti-HIV-1 activity of a series of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs) are reported. These compounds were synthesized via a coupling reaction of the corresponding 6-benzyl-2-thiouracils with aryl iodides in the presence of neocuproine hydrate, copper(I) iodide, and sodium tert-butoxide. Target compounds showed moderate activity against HIV-1.

AB - The synthesis and the anti-HIV-1 activity of a series of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs) are reported. These compounds were synthesized via a coupling reaction of the corresponding 6-benzyl-2-thiouracils with aryl iodides in the presence of neocuproine hydrate, copper(I) iodide, and sodium tert-butoxide. Target compounds showed moderate activity against HIV-1.

KW - medicinal chemistry; antiviral agents; HIV - non-nucleosides; S-DABO

U2 - 10.1055/s-2007-983732

DO - 10.1055/s-2007-983732

M3 - Journal article

VL - 13

SP - 1955

EP - 1960

JO - Synthesis

JF - Synthesis

SN - 0256-7245

ER -