Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides

A. K. Prasad, S. K. Singh, Neerja Kalra, N. Singhal, Jesper Wengel, Virinder S. Parmar

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Abstrakt

Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively in a highly selective and efficient manner.

OriginalsprogEngelsk
TidsskriftNucleosides, Nucleotides and Nucleic Acids
Vol/bind26
Udgave nummer10-12
Sider (fra-til)1517-1521
ISSN1525-7770
DOI
StatusUdgivet - 2007

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