Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing

Irina Astakhova, Dorthe Lindegaard, Vladimir A. Korshun, Jesper Wengel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Functionalisation of 2′-amino-LNA oligonucleotides with 1-, 2- and 4-(phenylethynyl)pyrene fluorophores via a carbonyl linker (PEPyc) resulted in efficient interstrand communication systems in nucleic acid duplexes, providing effective tools for stabilization of nanostructures and fluorescence monitoring of DNA self-assembly
OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind46
Udgave nummer44
Sider (fra-til)8362-8364
ISSN1359-7345
DOI
StatusUdgivet - 2010

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