Normal lymph node size at Endobronchial ultrasound guided Transbronchial needle aspiration correlates to benign cytopathological diagnosis but does not rule out malignancy

Ida Skovgaard Christiansen, Uffe Bødtger

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskning


Introduction Pleural effusion (PE) is a common condition. Malignancy accounts for lt;25% in general populations. The proportion is unknown in patients referred to pulmonologists for workup.Finding malignant cells in PE by thoracentesis suggests metastatic and incurable disease making further tests and staging procedures superfluous.Objectives In patients with PE referred to pulmonologists for workup, we wanted to ascertain A) risk of malignancy; B)diagnostic yield of a single thoracentesis; C)time from PE to diagnosis; and D)impact of finding malignant cells in PE on use of additional tests.Methods Retrospective, observational study including all patients referred 01.01.2013 to 31.12.2014 to the Dep. of Pulmonology, Odense University Hospital, Denmark, and having a thoracentesis performed. Data were collected from electronic medical file.Results In total, 138 patients were identified, and 78 (57 were diagnosed with malignancy. A single thoracentesis diagnosed PE malignancy in 39 (28 patients: these patients had significantly shorter time from thoracentesis to final diagnosis compared to those without PE malignancy (n=99), and to those with malignancy diagnosed by other tests (n=39). Use of PET, bronchoscopy and thoracoscopy did not differ between groups.Conclusion Malignancy is the most likely diagnosis in patients with PE referred to pulmonologists. Half of cases were diagnosed by thoracentesis but without a reduction in number of investigations used. Additional tissue for advanced immunohistochemistry, or same-day investigational procedures might be underlying causes for this discrepancy.
TidsskriftEuropean Respiratory Journal
Udgave nummerSuppl. 60
StatusUdgivet - 2016
BegivenhedEuropean Respiratory Society International Congress 2016 - London EXCEL, London, Storbritannien
Varighed: 3. sep. 20167. sep. 2016


KonferenceEuropean Respiratory Society International Congress 2016
LokationLondon EXCEL