Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside

Søren Leer Blindbæk, Thomas Lee Torp, Kristian Lundberg, Kerstin Soelberg, Anna Stage Vergmann, Christina Døfler Poulsen, Ulrik Frydkjær-Olsen, Rebecca Broe, Malin Lundberg Rasmussen, Jimmi Wied, Majbrit Lind, Anders Højslet Vestergaard, Tunde Peto, Jakob Grauslund

Publikation: Bidrag til tidsskriftReviewForskningpeer review

210 Downloads (Pure)

Resumé

The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.
OriginalsprogEngelsk
Artikelnummer2562759
TidsskriftJournal of Diabetes Research
Vol/bind2017
Antal sider10
ISSN2314-6745
DOI
StatusUdgivet - 13. apr. 2017

Emneord

  • Diabetes
  • Øjensygdomme
  • Oftamologi
  • Diabetiske øjensygdomme

Citer dette

Blindbæk, Søren Leer ; Torp, Thomas Lee ; Lundberg, Kristian ; Soelberg, Kerstin ; Vergmann, Anna Stage ; Poulsen, Christina Døfler ; Frydkjær-Olsen, Ulrik ; Broe, Rebecca ; Rasmussen, Malin Lundberg ; Wied, Jimmi ; Lind, Majbrit ; Vestergaard, Anders Højslet ; Peto, Tunde ; Grauslund, Jakob. / Noninvasive Retinal Markers in Diabetic Retinopathy : Advancing from Bench towards Bedside. I: Journal of Diabetes Research. 2017 ; Bind 2017.
@article{a334f5532ddd4301b0a39400085584e8,
title = "Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside",
abstract = "The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.",
keywords = "Diabetes, {\O}jensygdomme, Oftamologi, Diabetiske {\o}jensygdomme",
author = "Blindb{\ae}k, {S{\o}ren Leer} and Torp, {Thomas Lee} and Kristian Lundberg and Kerstin Soelberg and Vergmann, {Anna Stage} and Poulsen, {Christina D{\o}fler} and Ulrik Frydkj{\ae}r-Olsen and Rebecca Broe and Rasmussen, {Malin Lundberg} and Jimmi Wied and Majbrit Lind and Vestergaard, {Anders H{\o}jslet} and Tunde Peto and Jakob Grauslund",
year = "2017",
month = "4",
day = "13",
doi = "10.1155/2017/2562759",
language = "English",
volume = "2017",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

Noninvasive Retinal Markers in Diabetic Retinopathy : Advancing from Bench towards Bedside. / Blindbæk, Søren Leer; Torp, Thomas Lee; Lundberg, Kristian ; Soelberg, Kerstin; Vergmann, Anna Stage; Poulsen, Christina Døfler; Frydkjær-Olsen, Ulrik; Broe, Rebecca; Rasmussen, Malin Lundberg; Wied, Jimmi; Lind, Majbrit; Vestergaard, Anders Højslet; Peto, Tunde ; Grauslund, Jakob.

I: Journal of Diabetes Research, Bind 2017, 2562759, 13.04.2017.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Noninvasive Retinal Markers in Diabetic Retinopathy

T2 - Advancing from Bench towards Bedside

AU - Blindbæk, Søren Leer

AU - Torp, Thomas Lee

AU - Lundberg, Kristian

AU - Soelberg, Kerstin

AU - Vergmann, Anna Stage

AU - Poulsen, Christina Døfler

AU - Frydkjær-Olsen, Ulrik

AU - Broe, Rebecca

AU - Rasmussen, Malin Lundberg

AU - Wied, Jimmi

AU - Lind, Majbrit

AU - Vestergaard, Anders Højslet

AU - Peto, Tunde

AU - Grauslund, Jakob

PY - 2017/4/13

Y1 - 2017/4/13

N2 - The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.

AB - The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.

KW - Diabetes

KW - Øjensygdomme

KW - Oftamologi

KW - Diabetiske øjensygdomme

U2 - 10.1155/2017/2562759

DO - 10.1155/2017/2562759

M3 - Review

C2 - 28491870

VL - 2017

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 2562759

ER -