Non-specific effects of vaccines: Current evidence and potential implications

Charlotte L.C.J. de Bree, Valerie A.C.M. Koeken, Leo A.B. Joosten, Peter Aaby, Christine Stabell Benn, Reinout van Crevel, Mihai G. Netea*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations have been confirmed in randomized trials. Immunological mechanisms mediating NSE include heterologous lymphocyte effects and induction of innate immune memory (trained immunity). Trained immunity induces long-term functional upregulation of innate immune cells through epigenetic and metabolic reprogramming. An overview of the epidemiological evidence of non-specific effects of vaccines and the latest insights regarding the biological mechanisms behind this phenomenon is presented, and future research priorities and potential implications are discussed.

OriginalsprogEngelsk
TidsskriftSeminars in Immunology
Vol/bind39
Sider (fra-til)35-43
ISSN1044-5323
DOI
StatusUdgivet - okt. 2018

Fingeraftryk

Attenuated Vaccines
Epigenomics
Up-Regulation
Research

Citer dette

de Bree, Charlotte L.C.J. ; Koeken, Valerie A.C.M. ; Joosten, Leo A.B. ; Aaby, Peter ; Benn, Christine Stabell ; van Crevel, Reinout ; Netea, Mihai G. / Non-specific effects of vaccines : Current evidence and potential implications. I: Seminars in Immunology. 2018 ; Bind 39. s. 35-43.
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title = "Non-specific effects of vaccines: Current evidence and potential implications",
abstract = "Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Gu{\'e}rin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations have been confirmed in randomized trials. Immunological mechanisms mediating NSE include heterologous lymphocyte effects and induction of innate immune memory (trained immunity). Trained immunity induces long-term functional upregulation of innate immune cells through epigenetic and metabolic reprogramming. An overview of the epidemiological evidence of non-specific effects of vaccines and the latest insights regarding the biological mechanisms behind this phenomenon is presented, and future research priorities and potential implications are discussed.",
keywords = "Heterologous protection, Morbidity, Mortality, Non-specific effects, Trained immunity, Vaccines",
author = "{de Bree}, {Charlotte L.C.J.} and Koeken, {Valerie A.C.M.} and Joosten, {Leo A.B.} and Peter Aaby and Benn, {Christine Stabell} and {van Crevel}, Reinout and Netea, {Mihai G.}",
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Non-specific effects of vaccines : Current evidence and potential implications. / de Bree, Charlotte L.C.J.; Koeken, Valerie A.C.M.; Joosten, Leo A.B.; Aaby, Peter; Benn, Christine Stabell; van Crevel, Reinout; Netea, Mihai G.

I: Seminars in Immunology, Bind 39, 10.2018, s. 35-43.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Non-specific effects of vaccines

T2 - Current evidence and potential implications

AU - de Bree, Charlotte L.C.J.

AU - Koeken, Valerie A.C.M.

AU - Joosten, Leo A.B.

AU - Aaby, Peter

AU - Benn, Christine Stabell

AU - van Crevel, Reinout

AU - Netea, Mihai G.

PY - 2018/10

Y1 - 2018/10

N2 - Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations have been confirmed in randomized trials. Immunological mechanisms mediating NSE include heterologous lymphocyte effects and induction of innate immune memory (trained immunity). Trained immunity induces long-term functional upregulation of innate immune cells through epigenetic and metabolic reprogramming. An overview of the epidemiological evidence of non-specific effects of vaccines and the latest insights regarding the biological mechanisms behind this phenomenon is presented, and future research priorities and potential implications are discussed.

AB - Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations have been confirmed in randomized trials. Immunological mechanisms mediating NSE include heterologous lymphocyte effects and induction of innate immune memory (trained immunity). Trained immunity induces long-term functional upregulation of innate immune cells through epigenetic and metabolic reprogramming. An overview of the epidemiological evidence of non-specific effects of vaccines and the latest insights regarding the biological mechanisms behind this phenomenon is presented, and future research priorities and potential implications are discussed.

KW - Heterologous protection

KW - Morbidity

KW - Mortality

KW - Non-specific effects

KW - Trained immunity

KW - Vaccines

U2 - 10.1016/j.smim.2018.06.002

DO - 10.1016/j.smim.2018.06.002

M3 - Review

C2 - 30007489

AN - SCOPUS:85049622486

VL - 39

SP - 35

EP - 43

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

ER -