Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders: An updated systematic literature review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Background and objectives The primary treatment for schizophrenia and schizophrenia-spectrum disorders is antipsychotic medication. One of the many public health challenges in mental illness, is to identify contributing factors to non-adherence to pharmacological treatment. The objective of this study was to perform an updated systematic review of risk factors for non-adherence to pharmacological treatment in schizophrenia in a European and American context. Methods The study was a systematic literature review of studies that included at least two measurements of pharmacological adherence in adult schizophrenic patients. This was done to validate the measures of adherence adequately which is rarely done in previous adherence research. It was conducted using PRISMA guidelines surveying Pubmed and PsycINFO. Results The definition of non-adherence varies greatly in eligible studies and the methodological approach to investigation of non-adherence is inconsistent. Thirteen studies fit the inclusion criteria and demonstrated several risk factors statistically influencing non-adherence rates. The most frequent risk factors identified for non-adherence were poor insight into or lack of awareness of illness, alcohol or drug abuse and unspecified younger age. Conclusions The findings in this systematic literature review are consistent with previous reviews on non-adherence and schizophrenia. It stresses the methodological challenges in psychiatric adherence research and establishes the need for more systematic and rigorous study design and methods within this field.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Psychiatry
Vol/bind31
Udgave nummer4
Sider (fra-til)172-186
ISSN0213-6163
DOI
StatusUdgivet - 2017

Fingeraftryk

Research
PubMed
Alcoholism
Public Health
Guidelines

Citer dette

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title = "Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders: An updated systematic literature review",
abstract = "Background and objectives The primary treatment for schizophrenia and schizophrenia-spectrum disorders is antipsychotic medication. One of the many public health challenges in mental illness, is to identify contributing factors to non-adherence to pharmacological treatment. The objective of this study was to perform an updated systematic review of risk factors for non-adherence to pharmacological treatment in schizophrenia in a European and American context. Methods The study was a systematic literature review of studies that included at least two measurements of pharmacological adherence in adult schizophrenic patients. This was done to validate the measures of adherence adequately which is rarely done in previous adherence research. It was conducted using PRISMA guidelines surveying Pubmed and PsycINFO. Results The definition of non-adherence varies greatly in eligible studies and the methodological approach to investigation of non-adherence is inconsistent. Thirteen studies fit the inclusion criteria and demonstrated several risk factors statistically influencing non-adherence rates. The most frequent risk factors identified for non-adherence were poor insight into or lack of awareness of illness, alcohol or drug abuse and unspecified younger age. Conclusions The findings in this systematic literature review are consistent with previous reviews on non-adherence and schizophrenia. It stresses the methodological challenges in psychiatric adherence research and establishes the need for more systematic and rigorous study design and methods within this field.",
keywords = "Antipsychotics, Epidemiology, Non-adherence, Pharmacological treatment, Schizophrenia",
author = "Ljungdalh, {P. M.}",
year = "2017",
doi = "10.1016/j.ejpsy.2017.08.001",
language = "English",
volume = "31",
pages = "172--186",
journal = "The European Journal of Psychiatry",
issn = "0213-6163",
publisher = "Universidad de Zaragoza Facultad de Medicina",
number = "4",

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TY - JOUR

T1 - Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders

T2 - An updated systematic literature review

AU - Ljungdalh, P. M.

PY - 2017

Y1 - 2017

N2 - Background and objectives The primary treatment for schizophrenia and schizophrenia-spectrum disorders is antipsychotic medication. One of the many public health challenges in mental illness, is to identify contributing factors to non-adherence to pharmacological treatment. The objective of this study was to perform an updated systematic review of risk factors for non-adherence to pharmacological treatment in schizophrenia in a European and American context. Methods The study was a systematic literature review of studies that included at least two measurements of pharmacological adherence in adult schizophrenic patients. This was done to validate the measures of adherence adequately which is rarely done in previous adherence research. It was conducted using PRISMA guidelines surveying Pubmed and PsycINFO. Results The definition of non-adherence varies greatly in eligible studies and the methodological approach to investigation of non-adherence is inconsistent. Thirteen studies fit the inclusion criteria and demonstrated several risk factors statistically influencing non-adherence rates. The most frequent risk factors identified for non-adherence were poor insight into or lack of awareness of illness, alcohol or drug abuse and unspecified younger age. Conclusions The findings in this systematic literature review are consistent with previous reviews on non-adherence and schizophrenia. It stresses the methodological challenges in psychiatric adherence research and establishes the need for more systematic and rigorous study design and methods within this field.

AB - Background and objectives The primary treatment for schizophrenia and schizophrenia-spectrum disorders is antipsychotic medication. One of the many public health challenges in mental illness, is to identify contributing factors to non-adherence to pharmacological treatment. The objective of this study was to perform an updated systematic review of risk factors for non-adherence to pharmacological treatment in schizophrenia in a European and American context. Methods The study was a systematic literature review of studies that included at least two measurements of pharmacological adherence in adult schizophrenic patients. This was done to validate the measures of adherence adequately which is rarely done in previous adherence research. It was conducted using PRISMA guidelines surveying Pubmed and PsycINFO. Results The definition of non-adherence varies greatly in eligible studies and the methodological approach to investigation of non-adherence is inconsistent. Thirteen studies fit the inclusion criteria and demonstrated several risk factors statistically influencing non-adherence rates. The most frequent risk factors identified for non-adherence were poor insight into or lack of awareness of illness, alcohol or drug abuse and unspecified younger age. Conclusions The findings in this systematic literature review are consistent with previous reviews on non-adherence and schizophrenia. It stresses the methodological challenges in psychiatric adherence research and establishes the need for more systematic and rigorous study design and methods within this field.

KW - Antipsychotics

KW - Epidemiology

KW - Non-adherence

KW - Pharmacological treatment

KW - Schizophrenia

U2 - 10.1016/j.ejpsy.2017.08.001

DO - 10.1016/j.ejpsy.2017.08.001

M3 - Review

AN - SCOPUS:85036541031

VL - 31

SP - 172

EP - 186

JO - The European Journal of Psychiatry

JF - The European Journal of Psychiatry

SN - 0213-6163

IS - 4

ER -