No evidence of transmission of chronic lymphocytic leukemia through blood transfusion

Henrik Hjalgrim, Klaus Rostgaard, Senthil K Vasan, Henrik Ullum, Christian Erikstrup, Ole B V Pedersen, Kaspar R Nielsen, Kjell-Einar Titlestad, Mads Melbye, Olof Nyrén, Gustaf Edgren

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

OriginalsprogEngelsk
TidsskriftBlood
Vol/bind126
Udgave nummer17
Sider (fra-til)2059-2061
ISSN0006-4971
DOI
StatusUdgivet - 2015

Fingeraftryk

B-Cell Chronic Lymphocytic Leukemia
Lymphocytosis
Databases
Cluster Analysis
Confidence Intervals
Health

Citer dette

Hjalgrim, H., Rostgaard, K., Vasan, S. K., Ullum, H., Erikstrup, C., Pedersen, O. B. V., ... Edgren, G. (2015). No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. Blood, 126(17), 2059-2061 . https://doi.org/10.1182/blood-2015-03-632844
Hjalgrim, Henrik ; Rostgaard, Klaus ; Vasan, Senthil K ; Ullum, Henrik ; Erikstrup, Christian ; Pedersen, Ole B V ; Nielsen, Kaspar R ; Titlestad, Kjell-Einar ; Melbye, Mads ; Nyrén, Olof ; Edgren, Gustaf. / No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. I: Blood. 2015 ; Bind 126, Nr. 17. s. 2059-2061 .
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title = "No evidence of transmission of chronic lymphocytic leukemia through blood transfusion",
abstract = "Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95{\%} confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.",
author = "Henrik Hjalgrim and Klaus Rostgaard and Vasan, {Senthil K} and Henrik Ullum and Christian Erikstrup and Pedersen, {Ole B V} and Nielsen, {Kaspar R} and Kjell-Einar Titlestad and Mads Melbye and Olof Nyr{\'e}n and Gustaf Edgren",
note = "{\circledC} 2015 by The American Society of Hematology.",
year = "2015",
doi = "10.1182/blood-2015-03-632844",
language = "English",
volume = "126",
pages = "2059--2061",
journal = "Blood",
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Hjalgrim, H, Rostgaard, K, Vasan, SK, Ullum, H, Erikstrup, C, Pedersen, OBV, Nielsen, KR, Titlestad, K-E, Melbye, M, Nyrén, O & Edgren, G 2015, 'No evidence of transmission of chronic lymphocytic leukemia through blood transfusion', Blood, bind 126, nr. 17, s. 2059-2061 . https://doi.org/10.1182/blood-2015-03-632844

No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. / Hjalgrim, Henrik; Rostgaard, Klaus; Vasan, Senthil K; Ullum, Henrik; Erikstrup, Christian; Pedersen, Ole B V; Nielsen, Kaspar R; Titlestad, Kjell-Einar; Melbye, Mads; Nyrén, Olof; Edgren, Gustaf.

I: Blood, Bind 126, Nr. 17, 2015, s. 2059-2061 .

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - No evidence of transmission of chronic lymphocytic leukemia through blood transfusion

AU - Hjalgrim, Henrik

AU - Rostgaard, Klaus

AU - Vasan, Senthil K

AU - Ullum, Henrik

AU - Erikstrup, Christian

AU - Pedersen, Ole B V

AU - Nielsen, Kaspar R

AU - Titlestad, Kjell-Einar

AU - Melbye, Mads

AU - Nyrén, Olof

AU - Edgren, Gustaf

N1 - © 2015 by The American Society of Hematology.

PY - 2015

Y1 - 2015

N2 - Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

AB - Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

U2 - 10.1182/blood-2015-03-632844

DO - 10.1182/blood-2015-03-632844

M3 - Journal article

C2 - 26302757

VL - 126

SP - 2059

EP - 2061

JO - Blood

JF - Blood

SN - 0006-4971

IS - 17

ER -