No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Mar
OriginalsprogEngelsk
TidsskriftBiomarkers
Vol/bind14
Udgave nummer2
Sider (fra-til)67-76
Antal sider9
ISSN1354-750X
DOI
StatusUdgivet - 1. mar. 2009

Fingeraftryk

Lymphocytes
Polychlorinated Biphenyls
Monoamine Oxidase
Neurology
Biomarkers
Muscarinic Receptors
Platelets
Central Nervous System
Blood
Cholinergic Receptors
Cholinergic Agents
Neuropsychological Tests
Drug Users
Pharmaceutical Preparations
Proteins

Citer dette

@article{a537950027a311dfba21000ea68e967b,
title = "No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls",
abstract = "Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). Blood samples from 7-year-old exposed children were analyzed for platelet MAO-B and lymphocyte mAChRs as potential markers of exposure to these neurotoxicants. The blood neurotoxicity biomarkers were compared with prenatal and current exposures and with neuropsychological test results. Both biomarkers showed homogeneous distributions within this cohort (mAChR, range 0.04-36.78 fmol/million cells; MAO-B, 0.95-14.95 nmol mg(-1) protein h(-1)). No correlation was found between the two biomarkers and either blood neurotoxicant concentrations or clinical findings. MAO-B and mAChR sensitivity may not be sufficiently high to assess early, subclinical responses to low/moderate methylmercury and/or PCB exposure, whereas these markers are significantly altered in sustained exposure scenarios, as shown by clinical studies in drug addicts or patients treated with psychopharmacological agents.",
keywords = "Biological Markers, Blood Platelets, Child, Cohort Studies, Female, Humans, Lymphocytes, Male, Methylmercury Compounds, Monoamine Oxidase, Neuropsychological Tests, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects",
author = "Teresa Coccini and Luigi Manzo and Frodi Debes and Ulrike Steuerwald and Pal Weihe and Philippe Grandjean",
year = "2009",
month = "3",
day = "1",
doi = "10.1080/13547500902783739",
language = "English",
volume = "14",
pages = "67--76",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Taylor & Francis",
number = "2",

}

TY - JOUR

T1 - No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls

AU - Coccini, Teresa

AU - Manzo, Luigi

AU - Debes, Frodi

AU - Steuerwald, Ulrike

AU - Weihe, Pal

AU - Grandjean, Philippe

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). Blood samples from 7-year-old exposed children were analyzed for platelet MAO-B and lymphocyte mAChRs as potential markers of exposure to these neurotoxicants. The blood neurotoxicity biomarkers were compared with prenatal and current exposures and with neuropsychological test results. Both biomarkers showed homogeneous distributions within this cohort (mAChR, range 0.04-36.78 fmol/million cells; MAO-B, 0.95-14.95 nmol mg(-1) protein h(-1)). No correlation was found between the two biomarkers and either blood neurotoxicant concentrations or clinical findings. MAO-B and mAChR sensitivity may not be sufficiently high to assess early, subclinical responses to low/moderate methylmercury and/or PCB exposure, whereas these markers are significantly altered in sustained exposure scenarios, as shown by clinical studies in drug addicts or patients treated with psychopharmacological agents.

AB - Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). Blood samples from 7-year-old exposed children were analyzed for platelet MAO-B and lymphocyte mAChRs as potential markers of exposure to these neurotoxicants. The blood neurotoxicity biomarkers were compared with prenatal and current exposures and with neuropsychological test results. Both biomarkers showed homogeneous distributions within this cohort (mAChR, range 0.04-36.78 fmol/million cells; MAO-B, 0.95-14.95 nmol mg(-1) protein h(-1)). No correlation was found between the two biomarkers and either blood neurotoxicant concentrations or clinical findings. MAO-B and mAChR sensitivity may not be sufficiently high to assess early, subclinical responses to low/moderate methylmercury and/or PCB exposure, whereas these markers are significantly altered in sustained exposure scenarios, as shown by clinical studies in drug addicts or patients treated with psychopharmacological agents.

KW - Biological Markers

KW - Blood Platelets

KW - Child

KW - Cohort Studies

KW - Female

KW - Humans

KW - Lymphocytes

KW - Male

KW - Methylmercury Compounds

KW - Monoamine Oxidase

KW - Neuropsychological Tests

KW - Polychlorinated Biphenyls

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

U2 - 10.1080/13547500902783739

DO - 10.1080/13547500902783739

M3 - Journal article

VL - 14

SP - 67

EP - 76

JO - Biomarkers

JF - Biomarkers

SN - 1354-750X

IS - 2

ER -