No Ameliorating Effect of Surfactant Protein D on DSS-Induced Colitis in Mice

Anders Bathum Nexøe; Bartosz Pilecki; Steffen Husby; Uffe Holmskov; Grith Lykke Sørensen

No Ameliorating Effect of Surfactant Protein D on DSS-Induced Colitis in Mice

Anders Bathum Nexøe, Bartosz Pilecki, Steffen Husby, Uffe Holmskov, Grith Lykke Sørensen

KI, OUH, Forskningsenhed for Pædiatri (Odense)

Publikation: Konferencebidrag uden forlag/tidsskrift › Konferenceabstrakt til konference › Forskning › peer review

Abstract

Inflammatory bowel diseases (IBD) are disorders associated to a pathological immune response. Surfactant protein D (SP-D) is part of the innate host defense and has known anti-inflammatory effects. We hypothesize that SP-D dampens dextran sodium sulfate (DSS)-induced colitis by reducing innate inflammatory signaling and facilitation clearance of apoptotic cells. We induced experimental colitis in C57BL/6N Sftpd-/- (KO) and Sftpd+/+ (WT) mice by administration of 1% or 1.5% DSS for 7 days.

Originalsprog	Dansk
Publikationsdato	2016
Antal sider	1
Status	Udgivet - 2016
Begivenhed	10th European Mucosal Immunology Group Meeting - DGI-Byen, Copenhagen, Danmark Varighed: 19. okt. 2016 → 21. okt. 2016 http://emig2016.org/

Konference

Konference	10th European Mucosal Immunology Group Meeting
Lokation	DGI-Byen
Land/Område	Danmark
By	Copenhagen
Periode	19/10/2016 → 21/10/2016
Internetadresse	http://emig2016.org/

Citationsformater

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title = "No Ameliorating Effect of Surfactant Protein D on DSS-Induced Colitis in Mice",

abstract = "Inflammatory bowel diseases (IBD) are disorders associated to a pathological immune response. Surfactant protein D (SP-D) is part of the innate host defense and has known anti-inflammatory effects. We hypothesize that SP-D dampens dextran sodium sulfate (DSS)-induced colitis by reducing innate inflammatory signaling and facilitation clearance of apoptotic cells. We induced experimental colitis in C57BL/6N Sftpd-/- (KO) and Sftpd+/+ (WT) mice by administration of 1% or 1.5% DSS for 7 days. ",

author = "Nex{\o}e, {Anders Bathum} and Bartosz Pilecki and Steffen Husby and Uffe Holmskov and S{\o}rensen, {Grith Lykke}",

year = "2016",

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note = "10th European Mucosal Immunology Group Meeting, emig2016 ; Conference date: 19-10-2016 Through 21-10-2016",

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TY - ABST

T1 - No Ameliorating Effect of Surfactant Protein D on DSS-Induced Colitis in Mice

AU - Nexøe, Anders Bathum

AU - Pilecki, Bartosz

AU - Husby, Steffen

AU - Holmskov, Uffe

AU - Sørensen, Grith Lykke

PY - 2016

Y1 - 2016

N2 - Inflammatory bowel diseases (IBD) are disorders associated to a pathological immune response. Surfactant protein D (SP-D) is part of the innate host defense and has known anti-inflammatory effects. We hypothesize that SP-D dampens dextran sodium sulfate (DSS)-induced colitis by reducing innate inflammatory signaling and facilitation clearance of apoptotic cells. We induced experimental colitis in C57BL/6N Sftpd-/- (KO) and Sftpd+/+ (WT) mice by administration of 1% or 1.5% DSS for 7 days.

AB - Inflammatory bowel diseases (IBD) are disorders associated to a pathological immune response. Surfactant protein D (SP-D) is part of the innate host defense and has known anti-inflammatory effects. We hypothesize that SP-D dampens dextran sodium sulfate (DSS)-induced colitis by reducing innate inflammatory signaling and facilitation clearance of apoptotic cells. We induced experimental colitis in C57BL/6N Sftpd-/- (KO) and Sftpd+/+ (WT) mice by administration of 1% or 1.5% DSS for 7 days.

M3 - Konferenceabstrakt til konference

T2 - 10th European Mucosal Immunology Group Meeting

Y2 - 19 October 2016 through 21 October 2016

ER -