New strategies for targeting the therapy of NSCLC: The role of ERCC1 and TS

P. Ceppi*, M. Papotti, G. Scagliotti

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Abstrakt

The evaluation of gene and protein expression profiles is a promising strategy to drive the therapeutical decision-making in non-small cell lung cancer (NSCLC). Among the several candidate genes that have been proposed, many retrospective studies have indicated excision repair cross-complementing 1 (ERCC1), an endonuclease responsible for the repair of DNA damages, as a reliable biomarker of tumor sensitivity to platinum-based agents. Moreover, the recent evidences showing the clinical efficacy of next-generation multitargeted antifolate drugs, in NSCLC, have highlighted the role of the determination of thymidylate synthase (TS) expression levels. Here is presented a brief overview of the literature regarding these two genes that are currently under prospective investigation as predictive markers of treatment efficacy in NSCLC.

OriginalsprogEngelsk
TidsskriftAdvances in Medical Sciences
Vol/bind55
Udgave nummer1
Sider (fra-til)22-25
Antal sider4
ISSN1896-1126
DOI
StatusUdgivet - 1. jun. 2010

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