New recombinants within the MHC (B-complex) of the chicken.

C Koch, K Skjødt, A Toivanen, P Toivanen

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Abstrakt

In a search for genetic recombinations within the major histocompatibility complex (MHC) of the chicken, the B-complex, the offspring from matings between heterozygous B15/B21 and B4/B6 animals were analysed by red cell agglutination. Among the progeny, 8,912 informative typings were performed. Four recombinants were found, all separating the B-complex loci B-F and B-G (B-F codes for Class I antigens, B-G codes for an antigen of which there is no known homologue in mammals). B-L (Class II antigen) always followed B-F. Stimulation in graft versus host reactions and in mixed lymphocyte cultures followed B-F/B-L. The mapping distance between the two loci B-F and B-G is in the range of 0.04 centimorgan. The lack of recombinants separating individual B-F loci in this study and in the studies of others might indicate that chicken MHC is less complex than those of mammalian species, but alternative explanations are also possible. So far no serologically defined recombinant separating Class I (B-F) and Class II (B-L) loci has been found.
Udgivelsesdato: 1983-Feb
OriginalsprogEngelsk
TidsskriftHLA
Vol/bind21
Udgave nummer2
Sider (fra-til)129-37
Antal sider8
ISSN2059-2302
StatusUdgivet - 1. feb. 1983

Citationsformater

Koch, C., Skjødt, K., Toivanen, A., & Toivanen, P. (1983). New recombinants within the MHC (B-complex) of the chicken. HLA, 21(2), 129-37.