Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients

Camila Moreira Osório, Alexandra Latini, Rodrigo Bainy Leal, Maria Emília Rodrigues de Oliveira Thais, Helena Dresch Vascouto, Aline Pertile Remor, Mark William Lopes, Marcelo Neves Linhares, Juliana Ben, Roberta de Paula Martins, Rui Daniel Prediger, Alexandre Ademar Hoeller, Hans Joachim Markowitsch, Peter Wolf, Kátia Lin, Roger Walz*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n = 21), surgically treated patients with MTLE-HS (n = 32, left side = 17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency. We investigated whether enzymatic activities of the mitochondrial enzymes Complex I (C I), Complex II (C II), Complex IV (C IV) and Succinate Dehydrogenase (SDH) from the resected samples of the middle temporal neocortex (mTCx), amygdala (AMY) and hippocampus (HIP) were associated with performance in the RAVLT, LMII, BNT and fluency tests of our patients. After controlling for the side of hippocampus sclerosis, years of education, disease duration, antiepileptic treatment and seizure outcome after surgery, no independent associations were observed between the cognitive test scores and the analyzed mitochondrial enzymatic activities (p > 0.37). Results indicate that memory and language impairment observed in MTLE-HS patients are not strongly associated with the levels of mitochondrial CI, CII, SDH and C IV enzymatic activities in the temporal lobe structures ipsilateral to the HS lesion.

OriginalsprogEngelsk
TidsskriftEpilepsy Research
Vol/bind138
Sider (fra-til)26-31
ISSN0920-1211
DOI
StatusUdgivet - 2017

Fingeraftryk

Temporal Lobe Epilepsy
Pharmaceutical Preparations
Neocortex
Sclerosis
Language
Education
Enzymes

Citer dette

Osório, C. M., Latini, A., Leal, R. B., de Oliveira Thais, M. E. R., Vascouto, H. D., Remor, A. P., ... Walz, R. (2017). Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients. Epilepsy Research, 138, 26-31. https://doi.org/10.1016/j.eplepsyres.2017.10.009
Osório, Camila Moreira ; Latini, Alexandra ; Leal, Rodrigo Bainy ; de Oliveira Thais, Maria Emília Rodrigues ; Vascouto, Helena Dresch ; Remor, Aline Pertile ; Lopes, Mark William ; Linhares, Marcelo Neves ; Ben, Juliana ; de Paula Martins, Roberta ; Prediger, Rui Daniel ; Hoeller, Alexandre Ademar ; Markowitsch, Hans Joachim ; Wolf, Peter ; Lin, Kátia ; Walz, Roger. / Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients. I: Epilepsy Research. 2017 ; Bind 138. s. 26-31.
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title = "Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients",
abstract = "Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n = 21), surgically treated patients with MTLE-HS (n = 32, left side = 17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency. We investigated whether enzymatic activities of the mitochondrial enzymes Complex I (C I), Complex II (C II), Complex IV (C IV) and Succinate Dehydrogenase (SDH) from the resected samples of the middle temporal neocortex (mTCx), amygdala (AMY) and hippocampus (HIP) were associated with performance in the RAVLT, LMII, BNT and fluency tests of our patients. After controlling for the side of hippocampus sclerosis, years of education, disease duration, antiepileptic treatment and seizure outcome after surgery, no independent associations were observed between the cognitive test scores and the analyzed mitochondrial enzymatic activities (p > 0.37). Results indicate that memory and language impairment observed in MTLE-HS patients are not strongly associated with the levels of mitochondrial CI, CII, SDH and C IV enzymatic activities in the temporal lobe structures ipsilateral to the HS lesion.",
keywords = "Brain metabolism, Cognition, Hippocampus, Temporal lobe epilepsy",
author = "Os{\'o}rio, {Camila Moreira} and Alexandra Latini and Leal, {Rodrigo Bainy} and {de Oliveira Thais}, {Maria Em{\'i}lia Rodrigues} and Vascouto, {Helena Dresch} and Remor, {Aline Pertile} and Lopes, {Mark William} and Linhares, {Marcelo Neves} and Juliana Ben and {de Paula Martins}, Roberta and Prediger, {Rui Daniel} and Hoeller, {Alexandre Ademar} and Markowitsch, {Hans Joachim} and Peter Wolf and K{\'a}tia Lin and Roger Walz",
year = "2017",
doi = "10.1016/j.eplepsyres.2017.10.009",
language = "English",
volume = "138",
pages = "26--31",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",

}

Osório, CM, Latini, A, Leal, RB, de Oliveira Thais, MER, Vascouto, HD, Remor, AP, Lopes, MW, Linhares, MN, Ben, J, de Paula Martins, R, Prediger, RD, Hoeller, AA, Markowitsch, HJ, Wolf, P, Lin, K & Walz, R 2017, 'Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients', Epilepsy Research, bind 138, s. 26-31. https://doi.org/10.1016/j.eplepsyres.2017.10.009

Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients. / Osório, Camila Moreira; Latini, Alexandra; Leal, Rodrigo Bainy; de Oliveira Thais, Maria Emília Rodrigues; Vascouto, Helena Dresch; Remor, Aline Pertile; Lopes, Mark William; Linhares, Marcelo Neves; Ben, Juliana; de Paula Martins, Roberta; Prediger, Rui Daniel; Hoeller, Alexandre Ademar; Markowitsch, Hans Joachim; Wolf, Peter; Lin, Kátia; Walz, Roger.

I: Epilepsy Research, Bind 138, 2017, s. 26-31.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients

AU - Osório, Camila Moreira

AU - Latini, Alexandra

AU - Leal, Rodrigo Bainy

AU - de Oliveira Thais, Maria Emília Rodrigues

AU - Vascouto, Helena Dresch

AU - Remor, Aline Pertile

AU - Lopes, Mark William

AU - Linhares, Marcelo Neves

AU - Ben, Juliana

AU - de Paula Martins, Roberta

AU - Prediger, Rui Daniel

AU - Hoeller, Alexandre Ademar

AU - Markowitsch, Hans Joachim

AU - Wolf, Peter

AU - Lin, Kátia

AU - Walz, Roger

PY - 2017

Y1 - 2017

N2 - Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n = 21), surgically treated patients with MTLE-HS (n = 32, left side = 17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency. We investigated whether enzymatic activities of the mitochondrial enzymes Complex I (C I), Complex II (C II), Complex IV (C IV) and Succinate Dehydrogenase (SDH) from the resected samples of the middle temporal neocortex (mTCx), amygdala (AMY) and hippocampus (HIP) were associated with performance in the RAVLT, LMII, BNT and fluency tests of our patients. After controlling for the side of hippocampus sclerosis, years of education, disease duration, antiepileptic treatment and seizure outcome after surgery, no independent associations were observed between the cognitive test scores and the analyzed mitochondrial enzymatic activities (p > 0.37). Results indicate that memory and language impairment observed in MTLE-HS patients are not strongly associated with the levels of mitochondrial CI, CII, SDH and C IV enzymatic activities in the temporal lobe structures ipsilateral to the HS lesion.

AB - Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n = 21), surgically treated patients with MTLE-HS (n = 32, left side = 17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency. We investigated whether enzymatic activities of the mitochondrial enzymes Complex I (C I), Complex II (C II), Complex IV (C IV) and Succinate Dehydrogenase (SDH) from the resected samples of the middle temporal neocortex (mTCx), amygdala (AMY) and hippocampus (HIP) were associated with performance in the RAVLT, LMII, BNT and fluency tests of our patients. After controlling for the side of hippocampus sclerosis, years of education, disease duration, antiepileptic treatment and seizure outcome after surgery, no independent associations were observed between the cognitive test scores and the analyzed mitochondrial enzymatic activities (p > 0.37). Results indicate that memory and language impairment observed in MTLE-HS patients are not strongly associated with the levels of mitochondrial CI, CII, SDH and C IV enzymatic activities in the temporal lobe structures ipsilateral to the HS lesion.

KW - Brain metabolism

KW - Cognition

KW - Hippocampus

KW - Temporal lobe epilepsy

U2 - 10.1016/j.eplepsyres.2017.10.009

DO - 10.1016/j.eplepsyres.2017.10.009

M3 - Journal article

C2 - 29040828

AN - SCOPUS:85031087867

VL - 138

SP - 26

EP - 31

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -