Neuro-endocrine disruption in molluscs: Effects of pharmaceuticals on a serotonin- and dopamine dependent system

Henrik Holbech, Lene Bech Sanderhoff, Stine P. Waller, Knud Ladegaard Pedersen

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning


The Mollusca phylum is the second largest animal phylum with around 85,000 registered mollusc species and increasing attention to effects of chemicals on the molluscan endocrine system have been given during the last years. This includes initiation of the development of OECD test guidelines (TG) to assess the effect of chemicals in molluscs. To date no endocrine specific mollusc biomarkers have though been validated and included in draft test guidelines due to lack of knowledge of the endocrine system. Here we investigate effects of pharmaceuticals targeting serotonin and dopamine in a cost efficient and fast in vivo system using embryos of the freshwater pulmonate gastropod Lymnaea stagnalis (the great pond snail). It is known that serotonin and dopamine are involved in many reproductive processes in molluscs Incl. egg maturation and spawning and that pedal ciliary activity causing L. stagnalis embryos to rotate in the eggs is serotonin/dopamine regulated. We have developed a system to quantify embryo rotation and present results of exposure to serotonin, dopamine and different anti-depressive pharmaceuticals (e.g. selective serotonin reuptake inhibitors, SSRI´s) using the L. stagnalis embryo rotation test system.
Publikationsdato25. maj 2016
StatusUdgivet - 25. maj 2016
BegivenhedSETAC Europe 26th annual meeting: Environmental contaminants from land to sea: continuities and interface in environmental toxicology and chemistry - Nantes, Frankrig
Varighed: 22. maj 201626. jul. 2016


KonferenceSETAC Europe 26th annual meeting


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