Natural killer cell activity during premedication, anaesthesia and surgery

E Tønnesen, H Mickley, N Grunnet

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1983-Jun
OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind27
Udgave nummer3
Sider (fra-til)238-41
Antal sider3
ISSN0001-5172
StatusUdgivet - 1. jun. 1983

Fingeraftryk

Pancuronium
Hip Replacement Arthroplasties
Lymph Nodes

Citer dette

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title = "Natural killer cell activity during premedication, anaesthesia and surgery",
abstract = "Natural killer (NK) cell activity of peripheral blood mononuclear cells was measured against K-562 target cells in a 51Cr release assay in eight patients undergoing total hip replacement surgery. Eight consecutive blood samples were taken from each patient. A significant increase of NK cell activity was observed after premedication with diazepam per os. The activity increased further during a combined anaesthesia (thiopentone + N2O + O2 + buprenorphene + pancuronium) and remained increased during surgery. Postoperatively, NK cell activity fell and remained depressed for a period of at least 5 days. The findings of this study indicate that premedication, anaesthesia and surgery cause a rapid and transient increase in NK cell activity, followed by a decline in activity postoperatively. The transient increase in activity may be explained by mobilization of natural killer cells from extravasal space, spleen or lymph nodes into the circulation. The clinical significance of the alterations in NK cell activity is unknown and needs further investigation.",
keywords = "Aged, Anesthesia, General, Cell Line, Cytotoxicity, Immunologic, Female, Hip Prosthesis, Humans, Killer Cells, Natural, Leukemia, Erythroblastic, Acute, Male, Middle Aged, Postoperative Period, Preanesthetic Medication, Surgical Procedures, Operative",
author = "E T{\o}nnesen and H Mickley and N Grunnet",
year = "1983",
month = "6",
day = "1",
language = "English",
volume = "27",
pages = "238--41",
journal = "Acta Anaesthesiologica Scandinavica",
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publisher = "Wiley-Blackwell",
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Natural killer cell activity during premedication, anaesthesia and surgery. / Tønnesen, E; Mickley, H; Grunnet, N.

I: Acta Anaesthesiologica Scandinavica, Bind 27, Nr. 3, 01.06.1983, s. 238-41.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Natural killer cell activity during premedication, anaesthesia and surgery

AU - Tønnesen, E

AU - Mickley, H

AU - Grunnet, N

PY - 1983/6/1

Y1 - 1983/6/1

N2 - Natural killer (NK) cell activity of peripheral blood mononuclear cells was measured against K-562 target cells in a 51Cr release assay in eight patients undergoing total hip replacement surgery. Eight consecutive blood samples were taken from each patient. A significant increase of NK cell activity was observed after premedication with diazepam per os. The activity increased further during a combined anaesthesia (thiopentone + N2O + O2 + buprenorphene + pancuronium) and remained increased during surgery. Postoperatively, NK cell activity fell and remained depressed for a period of at least 5 days. The findings of this study indicate that premedication, anaesthesia and surgery cause a rapid and transient increase in NK cell activity, followed by a decline in activity postoperatively. The transient increase in activity may be explained by mobilization of natural killer cells from extravasal space, spleen or lymph nodes into the circulation. The clinical significance of the alterations in NK cell activity is unknown and needs further investigation.

AB - Natural killer (NK) cell activity of peripheral blood mononuclear cells was measured against K-562 target cells in a 51Cr release assay in eight patients undergoing total hip replacement surgery. Eight consecutive blood samples were taken from each patient. A significant increase of NK cell activity was observed after premedication with diazepam per os. The activity increased further during a combined anaesthesia (thiopentone + N2O + O2 + buprenorphene + pancuronium) and remained increased during surgery. Postoperatively, NK cell activity fell and remained depressed for a period of at least 5 days. The findings of this study indicate that premedication, anaesthesia and surgery cause a rapid and transient increase in NK cell activity, followed by a decline in activity postoperatively. The transient increase in activity may be explained by mobilization of natural killer cells from extravasal space, spleen or lymph nodes into the circulation. The clinical significance of the alterations in NK cell activity is unknown and needs further investigation.

KW - Aged

KW - Anesthesia, General

KW - Cell Line

KW - Cytotoxicity, Immunologic

KW - Female

KW - Hip Prosthesis

KW - Humans

KW - Killer Cells, Natural

KW - Leukemia, Erythroblastic, Acute

KW - Male

KW - Middle Aged

KW - Postoperative Period

KW - Preanesthetic Medication

KW - Surgical Procedures, Operative

M3 - Journal article

C2 - 6576593

VL - 27

SP - 238

EP - 241

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 3

ER -