Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

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Background: Theophylline, a dimethylxanthine, has been used the last 100 years to treat airway disease. Although it is one of the most widely prescribed medicines to treat asthma and chronic obstructive pulmonary disease (COPD) throughout the years, the utilisation patterns are not well-described. Methods: Using the Danish Register of Medicinal Products Statistics, we identified adults above 18 years redeeming one or more prescriptions of theophylline between 1997 up to 2017, with a 2-year run-in period from 1995 to 1997. Using descriptive statistics, we reported the development in prevalence, incidence, and a measure of treatment duration (proportion of patients covered). Results: In total, 55,636 individuals redeemed 1,066,475 prescriptions of theophylline, 30,619 women (55%) and 25,017 men (45%). The prevalence decreased from 401 per 100,000 individuals in 1997 to 26 per 100,000 individuals in 2016. The incidence rate decreased throughout the entire study period (105 per 100,000 person-years in 1997 to 5 per 100,000 person-years in 2016). In total, 52% were still current users three months after theophylline initiation, 33%, 27%, and 23% were current users after 6 months, one year, and two years. Conclusions: Although newer and more efficient medicines to treat asthma and COPD has been developed, theophylline is still prescribed and used in 2016, but the incidence and prevalence have decreased markedly since 1997.

OriginalsprogEngelsk
TidsskriftRespiratory Medicine
Vol/bind140
Sider (fra-til)57-62
ISSN0954-6111
DOI
StatusUdgivet - jul. 2018

Fingeraftryk

Drug Utilization
Chronic Obstructive Pulmonary Disease
Prescriptions
Incidence

Citer dette

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title = "Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study",
abstract = "Background: Theophylline, a dimethylxanthine, has been used the last 100 years to treat airway disease. Although it is one of the most widely prescribed medicines to treat asthma and chronic obstructive pulmonary disease (COPD) throughout the years, the utilisation patterns are not well-described. Methods: Using the Danish Register of Medicinal Products Statistics, we identified adults above 18 years redeeming one or more prescriptions of theophylline between 1997 up to 2017, with a 2-year run-in period from 1995 to 1997. Using descriptive statistics, we reported the development in prevalence, incidence, and a measure of treatment duration (proportion of patients covered). Results: In total, 55,636 individuals redeemed 1,066,475 prescriptions of theophylline, 30,619 women (55{\%}) and 25,017 men (45{\%}). The prevalence decreased from 401 per 100,000 individuals in 1997 to 26 per 100,000 individuals in 2016. The incidence rate decreased throughout the entire study period (105 per 100,000 person-years in 1997 to 5 per 100,000 person-years in 2016). In total, 52{\%} were still current users three months after theophylline initiation, 33{\%}, 27{\%}, and 23{\%} were current users after 6 months, one year, and two years. Conclusions: Although newer and more efficient medicines to treat asthma and COPD has been developed, theophylline is still prescribed and used in 2016, but the incidence and prevalence have decreased markedly since 1997.",
author = "Henriksen, {Daniel Pilsgaard} and Davidsen, {Jesper R{\o}mhild} and Laursen, {Christian B.}",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = "7",
doi = "10.1016/j.rmed.2018.05.015",
language = "English",
volume = "140",
pages = "57--62",
journal = "Respiratory Medicine",
issn = "0954-6111",
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}

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study. / Henriksen, Daniel Pilsgaard; Davidsen, Jesper Rømhild; Laursen, Christian B.

I: Respiratory Medicine, Bind 140, 07.2018, s. 57-62.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

AU - Henriksen, Daniel Pilsgaard

AU - Davidsen, Jesper Rømhild

AU - Laursen, Christian B.

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/7

Y1 - 2018/7

N2 - Background: Theophylline, a dimethylxanthine, has been used the last 100 years to treat airway disease. Although it is one of the most widely prescribed medicines to treat asthma and chronic obstructive pulmonary disease (COPD) throughout the years, the utilisation patterns are not well-described. Methods: Using the Danish Register of Medicinal Products Statistics, we identified adults above 18 years redeeming one or more prescriptions of theophylline between 1997 up to 2017, with a 2-year run-in period from 1995 to 1997. Using descriptive statistics, we reported the development in prevalence, incidence, and a measure of treatment duration (proportion of patients covered). Results: In total, 55,636 individuals redeemed 1,066,475 prescriptions of theophylline, 30,619 women (55%) and 25,017 men (45%). The prevalence decreased from 401 per 100,000 individuals in 1997 to 26 per 100,000 individuals in 2016. The incidence rate decreased throughout the entire study period (105 per 100,000 person-years in 1997 to 5 per 100,000 person-years in 2016). In total, 52% were still current users three months after theophylline initiation, 33%, 27%, and 23% were current users after 6 months, one year, and two years. Conclusions: Although newer and more efficient medicines to treat asthma and COPD has been developed, theophylline is still prescribed and used in 2016, but the incidence and prevalence have decreased markedly since 1997.

AB - Background: Theophylline, a dimethylxanthine, has been used the last 100 years to treat airway disease. Although it is one of the most widely prescribed medicines to treat asthma and chronic obstructive pulmonary disease (COPD) throughout the years, the utilisation patterns are not well-described. Methods: Using the Danish Register of Medicinal Products Statistics, we identified adults above 18 years redeeming one or more prescriptions of theophylline between 1997 up to 2017, with a 2-year run-in period from 1995 to 1997. Using descriptive statistics, we reported the development in prevalence, incidence, and a measure of treatment duration (proportion of patients covered). Results: In total, 55,636 individuals redeemed 1,066,475 prescriptions of theophylline, 30,619 women (55%) and 25,017 men (45%). The prevalence decreased from 401 per 100,000 individuals in 1997 to 26 per 100,000 individuals in 2016. The incidence rate decreased throughout the entire study period (105 per 100,000 person-years in 1997 to 5 per 100,000 person-years in 2016). In total, 52% were still current users three months after theophylline initiation, 33%, 27%, and 23% were current users after 6 months, one year, and two years. Conclusions: Although newer and more efficient medicines to treat asthma and COPD has been developed, theophylline is still prescribed and used in 2016, but the incidence and prevalence have decreased markedly since 1997.

U2 - 10.1016/j.rmed.2018.05.015

DO - 10.1016/j.rmed.2018.05.015

M3 - Journal article

C2 - 29957281

AN - SCOPUS:85047510361

VL - 140

SP - 57

EP - 62

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

ER -