National multi-centre study found a low prevalence of severely impaired lung function in children and adolescents

Ana Lukić, Frederik Buchvald, Lone Agertoft, Sune Rubak, Marianne Skov, Michael Perch, Kim G. Nielsen*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

AIM: As no data to our knowledge exist, the aim of the study was to describe the national prevalence and characteristics of Danish children and adolescents with severely impaired lung function.

METHODS: We performed a descriptive, cross-sectional Danish multi-centre study. Children and adolescents between 6 and 18 years old demonstrating severely impaired lung function from 2015 to 2018, defined by forced expiratory volume in 1 second (FEV1 ) <60% or who had lung transplantation, were eligible for inclusion.

RESULTS: This study included 113 children with a mean age (standard deviation) of 12.9 years (3.5 years). The prevalence of severely impaired lung function was approximately 13 in 100,000. The mean (standard deviation) FEV1 was 46.1% (10.1%) of predicted, and z-score was -4.5 (0.8). The most frequent diagnosis was cystic fibrosis (20.4%), followed by asthma (19.5%) and bronchiolitis obliterans (16.8%), while almost 25% had different elements of airway malformations or non-pulmonary conditions. Two adolescents with cystic fibrosis underwent lung transplantation.

CONCLUSION: The estimated prevalence of severely impaired lung function in Danish children and adolescents was low, and extremely, few children underwent lung transplantation. The most frequent diagnosis was cystic fibrosis, while almost 25% had different elements of airway malformations or non-pulmonary conditions, which may require clinical attention.

OriginalsprogEngelsk
TidsskriftActa Paediatrica, International Journal of Paediatrics
Vol/bind111
Udgave nummer5
Sider (fra-til)1044-1051
ISSN0803-5253
DOI
StatusUdgivet - maj 2022

Bibliografisk note

Funding Information:
Ana Lukic was financially supported by The Danish Foundation for Lung Diseases in Children (Børnelungefonden) 1 25‐75

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