N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma

Anne K Mylin, Jens P Goetze, Lene Heickendorff, Lucia Ahlberg, Inger Marie Dahl, Niels Abildgaard, Peter Gimsing, Nordic Myeloma Study Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

AIM: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.

MATERIALS & METHODS: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.

RESULTS: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.

CONCLUSION: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.

OriginalsprogEngelsk
TidsskriftBiomarkers in Medicine
Vol/bind9
Udgave nummer7
Sider (fra-til)679-689
Antal sider11
ISSN1752-0363
DOI
StatusUdgivet - jul. 2015

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