N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

M. Raunkjær, T. Bryld, J. Wengel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Resumé

Piperazino-functionalized 2′,3′-BcNA and 4′-C-hydroxymethyl-DNA are appropriate molecular architectures for the introduction of basic functionalities facing the major groove and the minor groove of nucleic acid duplexes, respectively. 4′-C-(N-Methylpiperazino)methyl-DNA monomers induce significantly increased thermal stability of a DNA:DNA duplex.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind2003
Udgave nummer13
Sider (fra-til)1604-1605
ISSN1359-7345
DOI
StatusUdgivet - 2003

Fingeraftryk

DNA
Nucleic acids
Nucleic Acids
Thermodynamic stability
Monomers

Citer dette

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title = "N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex",
abstract = "Piperazino-functionalized 2′,3′-BcNA and 4′-C-hydroxymethyl-DNA are appropriate molecular architectures for the introduction of basic functionalities facing the major groove and the minor groove of nucleic acid duplexes, respectively. 4′-C-(N-Methylpiperazino)methyl-DNA monomers induce significantly increased thermal stability of a DNA:DNA duplex.",
author = "M. Raunkj{\ae}r and T. Bryld and J. Wengel",
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doi = "10.1039/B302963H",
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publisher = "Royal Society of Chemistry",
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T1 - N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

AU - Raunkjær, M.

AU - Bryld, T.

AU - Wengel, J.

PY - 2003

Y1 - 2003

N2 - Piperazino-functionalized 2′,3′-BcNA and 4′-C-hydroxymethyl-DNA are appropriate molecular architectures for the introduction of basic functionalities facing the major groove and the minor groove of nucleic acid duplexes, respectively. 4′-C-(N-Methylpiperazino)methyl-DNA monomers induce significantly increased thermal stability of a DNA:DNA duplex.

AB - Piperazino-functionalized 2′,3′-BcNA and 4′-C-hydroxymethyl-DNA are appropriate molecular architectures for the introduction of basic functionalities facing the major groove and the minor groove of nucleic acid duplexes, respectively. 4′-C-(N-Methylpiperazino)methyl-DNA monomers induce significantly increased thermal stability of a DNA:DNA duplex.

U2 - 10.1039/B302963H

DO - 10.1039/B302963H

M3 - Journal article

VL - 2003

SP - 1604

EP - 1605

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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ER -