N-Acetylcysteine in the prevention of ototoxicity

Martin Tepel

doi:10.1038/sj.ki.5002299

N-Acetylcysteine in the prevention of ototoxicity

Martin Tepel

Charité - University Medicine Berlin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.

Originalsprog	Engelsk
Tidsskrift	Kidney International
Vol/bind	72
Udgave nummer	3
Sider (fra-til)	231-2
Antal sider	2
ISSN	0085-2538
DOI	https://doi.org/10.1038/sj.ki.5002299
Status	Udgivet - 2007
Udgivet eksternt	Ja

Dokumenter og links

10.1038/sj.ki.5002299

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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abstract = "Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.",

keywords = "Acetylcysteine, Administration, Oral, Aminoglycosides, Anti-Bacterial Agents, Antioxidants, Bacteremia, Gentamicins, Hearing Loss, Humans, Kidney Failure, Chronic, Renal Dialysis",

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journal = "Kidney International",

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AU - Tepel, Martin

PY - 2007

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N2 - Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.

AB - Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.

KW - Acetylcysteine

KW - Administration, Oral

KW - Aminoglycosides

KW - Anti-Bacterial Agents

KW - Antioxidants

KW - Bacteremia

KW - Gentamicins

KW - Hearing Loss

KW - Humans

KW - Kidney Failure, Chronic

KW - Renal Dialysis

U2 - 10.1038/sj.ki.5002299

DO - 10.1038/sj.ki.5002299

M3 - Journal article

C2 - 17653228

SN - 0085-2538

VL - 72

SP - 231

EP - 232

JO - Kidney International

JF - Kidney International

IS - 3

ER -

N-Acetylcysteine in the prevention of ototoxicity

Abstract

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater