N-Acetylcysteine in the prevention of ototoxicity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.
OriginalsprogEngelsk
TidsskriftKidney International
Vol/bind72
Udgave nummer3
Sider (fra-til)231-2
Antal sider2
ISSN0085-2538
DOI
StatusUdgivet - 2007

Fingeraftryk

Acetylcysteine

Citer dette

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title = "N-Acetylcysteine in the prevention of ototoxicity",
abstract = "Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.",
keywords = "Acetylcysteine, Administration, Oral, Aminoglycosides, Anti-Bacterial Agents, Antioxidants, Bacteremia, Gentamicins, Hearing Loss, Humans, Kidney Failure, Chronic, Renal Dialysis",
author = "Martin Tepel",
year = "2007",
doi = "10.1038/sj.ki.5002299",
language = "English",
volume = "72",
pages = "231--2",
journal = "Kidney International",
issn = "0085-2538",
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N-Acetylcysteine in the prevention of ototoxicity. / Tepel, Martin.

I: Kidney International, Bind 72, Nr. 3, 2007, s. 231-2.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - N-Acetylcysteine in the prevention of ototoxicity

AU - Tepel, Martin

PY - 2007

Y1 - 2007

N2 - Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.

AB - Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.

KW - Acetylcysteine

KW - Administration, Oral

KW - Aminoglycosides

KW - Anti-Bacterial Agents

KW - Antioxidants

KW - Bacteremia

KW - Gentamicins

KW - Hearing Loss

KW - Humans

KW - Kidney Failure, Chronic

KW - Renal Dialysis

U2 - 10.1038/sj.ki.5002299

DO - 10.1038/sj.ki.5002299

M3 - Journal article

VL - 72

SP - 231

EP - 232

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 3

ER -