N-Acetylaspartate-to-creatine ratio in twelve brain locations among healthy men and women with different levels of education

Jelena Ostojic, Dusko Kozic, Sergej M. Ostojic

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Brain bioenergetics could be affected by many intrinsic and extrinsic factors, yet no link has been established between markers of bioenergetics in specific brain regions and educational level. In this cross-sectional study, we evaluated N-acetylaspartate-to-creatine ratio (NAA/Cr), a biomarker of brain functionality, using multivoxel proton magnetic resonance spectroscopy in twelve brain locations among healthy volunteers (n = 51; 30 females; age 47.8 ± 16.3 years) who earned either a high school diploma (36 out of 51) or a college degree (15 out of 51). Hierarchical multiple regression analysis revealed that our model as a whole (including level of education as a predictor variable, and age and gender as control variables) explained significant percentage of the variance in the NAA/Cr levels at 8 out of 12 specific brain locations (P < 0.05). This was highlighted in left anterior mesial cortex where the model explained 63.1% of the variance in brain NAA/Cr, with education and age make significant contributions (72.6% and 48.5%, respectively) to our model (P < 0.05). Having superior brain N-acetylaspartate-to-creatine ratio appears to be related with higher education in healthy men and women.

OriginalsprogEngelsk
TidsskriftNeuroscience Letters
Vol/bind692
Sider (fra-til)23-26
ISSN0304-3940
DOI
StatusUdgivet - 23. jan. 2019

Fingeraftryk

Creatine
Education
Energy Metabolism
Intrinsic Factor
N-acetylaspartate
Cross-Sectional Studies
Regression Analysis

Citer dette

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title = "N-Acetylaspartate-to-creatine ratio in twelve brain locations among healthy men and women with different levels of education",
abstract = "Brain bioenergetics could be affected by many intrinsic and extrinsic factors, yet no link has been established between markers of bioenergetics in specific brain regions and educational level. In this cross-sectional study, we evaluated N-acetylaspartate-to-creatine ratio (NAA/Cr), a biomarker of brain functionality, using multivoxel proton magnetic resonance spectroscopy in twelve brain locations among healthy volunteers (n = 51; 30 females; age 47.8 ± 16.3 years) who earned either a high school diploma (36 out of 51) or a college degree (15 out of 51). Hierarchical multiple regression analysis revealed that our model as a whole (including level of education as a predictor variable, and age and gender as control variables) explained significant percentage of the variance in the NAA/Cr levels at 8 out of 12 specific brain locations (P < 0.05). This was highlighted in left anterior mesial cortex where the model explained 63.1{\%} of the variance in brain NAA/Cr, with education and age make significant contributions (72.6{\%} and 48.5{\%}, respectively) to our model (P < 0.05). Having superior brain N-acetylaspartate-to-creatine ratio appears to be related with higher education in healthy men and women.",
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N-Acetylaspartate-to-creatine ratio in twelve brain locations among healthy men and women with different levels of education. / Ostojic, Jelena; Kozic, Dusko; Ostojic, Sergej M.

I: Neuroscience Letters, Bind 692, 23.01.2019, s. 23-26.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - N-Acetylaspartate-to-creatine ratio in twelve brain locations among healthy men and women with different levels of education

AU - Ostojic, Jelena

AU - Kozic, Dusko

AU - Ostojic, Sergej M.

PY - 2019/1/23

Y1 - 2019/1/23

N2 - Brain bioenergetics could be affected by many intrinsic and extrinsic factors, yet no link has been established between markers of bioenergetics in specific brain regions and educational level. In this cross-sectional study, we evaluated N-acetylaspartate-to-creatine ratio (NAA/Cr), a biomarker of brain functionality, using multivoxel proton magnetic resonance spectroscopy in twelve brain locations among healthy volunteers (n = 51; 30 females; age 47.8 ± 16.3 years) who earned either a high school diploma (36 out of 51) or a college degree (15 out of 51). Hierarchical multiple regression analysis revealed that our model as a whole (including level of education as a predictor variable, and age and gender as control variables) explained significant percentage of the variance in the NAA/Cr levels at 8 out of 12 specific brain locations (P < 0.05). This was highlighted in left anterior mesial cortex where the model explained 63.1% of the variance in brain NAA/Cr, with education and age make significant contributions (72.6% and 48.5%, respectively) to our model (P < 0.05). Having superior brain N-acetylaspartate-to-creatine ratio appears to be related with higher education in healthy men and women.

AB - Brain bioenergetics could be affected by many intrinsic and extrinsic factors, yet no link has been established between markers of bioenergetics in specific brain regions and educational level. In this cross-sectional study, we evaluated N-acetylaspartate-to-creatine ratio (NAA/Cr), a biomarker of brain functionality, using multivoxel proton magnetic resonance spectroscopy in twelve brain locations among healthy volunteers (n = 51; 30 females; age 47.8 ± 16.3 years) who earned either a high school diploma (36 out of 51) or a college degree (15 out of 51). Hierarchical multiple regression analysis revealed that our model as a whole (including level of education as a predictor variable, and age and gender as control variables) explained significant percentage of the variance in the NAA/Cr levels at 8 out of 12 specific brain locations (P < 0.05). This was highlighted in left anterior mesial cortex where the model explained 63.1% of the variance in brain NAA/Cr, with education and age make significant contributions (72.6% and 48.5%, respectively) to our model (P < 0.05). Having superior brain N-acetylaspartate-to-creatine ratio appears to be related with higher education in healthy men and women.

KW - Bioenergetics

KW - Biomarker

KW - Brain

KW - Creatine

KW - Education

KW - N-Acetylaspartate

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DO - 10.1016/j.neulet.2018.10.050

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SP - 23

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JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

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