MyomiRs-133a/b turn off the heat

Jan-Wilhelm Kornfeld; Jens C Brüning

doi:10.1038/ncb2642

MyomiRs-133a/b turn off the heat

Jan-Wilhelm Kornfeld
, Jens C Brüning

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

Originalsprog	Engelsk
Tidsskrift	Nature Cell Biology
Vol/bind	14
Udgave nummer	12
Sider (fra-til)	1248-9
Antal sider	2
ISSN	1465-7392
DOI	https://doi.org/10.1038/ncb2642
Status	Udgivet - dec. 2012
Udgivet eksternt	Ja

Dokumenter og links

10.1038/ncb2642

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Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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abstract = "Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.",

keywords = "Adipocytes/cytology, Adipose Tissue, Brown/metabolism, Adipose Tissue, White/metabolism, Animals, DNA-Binding Proteins/metabolism, Humans, Male, MicroRNAs/metabolism, Transcription Factors/metabolism",

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AU - Kornfeld, Jan-Wilhelm

AU - Brüning, Jens C

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N2 - Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

AB - Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

KW - Adipocytes/cytology

KW - Adipose Tissue, Brown/metabolism

KW - Adipose Tissue, White/metabolism

KW - Animals

KW - DNA-Binding Proteins/metabolism

KW - Humans

KW - Male

KW - MicroRNAs/metabolism

KW - Transcription Factors/metabolism

U2 - 10.1038/ncb2642

DO - 10.1038/ncb2642

M3 - Journal article

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SP - 1248

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JO - Nature Cell Biology

JF - Nature Cell Biology

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ER -

MyomiRs-133a/b turn off the heat

Abstract

Dokumenter og links

SDU link

Fingeraftryk

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