MyomiRs-133a/b turn off the heat

Jan-Wilhelm Kornfeld, Jens C Brüning

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

OriginalsprogEngelsk
TidsskriftNature Cell Biology
Vol/bind14
Udgave nummer12
Sider (fra-til)1248-9
Antal sider2
ISSN1465-7392
DOI
StatusUdgivet - dec. 2012
Udgivet eksterntJa

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