Myeloproliferative Neoplasms in Danish Twins

Michael Asger Andersen, Ole Weis Bjerrum, Ajenthen Ranjan, Vibe Skov, Torben A Kruse, Mads Thomassen, Axel Skytthe, Hans Carl Hasselbalch, Kaare Christensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.
METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.
RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).
CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.
OriginalsprogEngelsk
TidsskriftActa Haematologica
Vol/bind139
Udgave nummer3
Sider (fra-til)195-198
ISSN0001-5792
DOI
StatusUdgivet - 3. maj 2018

Fingeraftryk

Neoplasms
Monozygotic Twins
Registries
Dizygotic Twins
Cell Lineage

Emneord

  • heredity
  • myeloproliferative neoplasms
  • Philadelphia-negative myeloproliferative neoplasms
  • registry studies
  • twins

Citer dette

Andersen, Michael Asger ; Bjerrum, Ole Weis ; Ranjan, Ajenthen ; Skov, Vibe ; Kruse, Torben A ; Thomassen, Mads ; Skytthe, Axel ; Hasselbalch, Hans Carl ; Christensen, Kaare. / Myeloproliferative Neoplasms in Danish Twins. I: Acta Haematologica. 2018 ; Bind 139, Nr. 3. s. 195-198.
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title = "Myeloproliferative Neoplasms in Danish Twins",
abstract = "OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0{\%}; p = 0.016).CONCLUSION: An estimated concordance rate of 15{\%} (95{\%} CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.",
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author = "Andersen, {Michael Asger} and Bjerrum, {Ole Weis} and Ajenthen Ranjan and Vibe Skov and Kruse, {Torben A} and Mads Thomassen and Axel Skytthe and Hasselbalch, {Hans Carl} and Kaare Christensen",
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Andersen, MA, Bjerrum, OW, Ranjan, A, Skov, V, Kruse, TA, Thomassen, M, Skytthe, A, Hasselbalch, HC & Christensen, K 2018, 'Myeloproliferative Neoplasms in Danish Twins', Acta Haematologica, bind 139, nr. 3, s. 195-198. https://doi.org/10.1159/000488384

Myeloproliferative Neoplasms in Danish Twins. / Andersen, Michael Asger; Bjerrum, Ole Weis; Ranjan, Ajenthen; Skov, Vibe; Kruse, Torben A; Thomassen, Mads; Skytthe, Axel; Hasselbalch, Hans Carl; Christensen, Kaare.

I: Acta Haematologica, Bind 139, Nr. 3, 03.05.2018, s. 195-198.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Myeloproliferative Neoplasms in Danish Twins

AU - Andersen, Michael Asger

AU - Bjerrum, Ole Weis

AU - Ranjan, Ajenthen

AU - Skov, Vibe

AU - Kruse, Torben A

AU - Thomassen, Mads

AU - Skytthe, Axel

AU - Hasselbalch, Hans Carl

AU - Christensen, Kaare

N1 - © 2018 S. Karger AG, Basel.

PY - 2018/5/3

Y1 - 2018/5/3

N2 - OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

AB - OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

KW - heredity

KW - myeloproliferative neoplasms

KW - Philadelphia-negative myeloproliferative neoplasms

KW - registry studies

KW - twins

KW - Heredity

KW - Myeloproliferative neoplasms

KW - Philadelphianegative myeloproliferative neoplasms

KW - Registry studies

KW - Twins

KW - Twins/statistics & numerical data

KW - Disease Susceptibility

KW - Myeloproliferative Disorders/epidemiology

KW - Humans

KW - Middle Aged

KW - Twins, Dizygotic

KW - Male

KW - Twins, Monozygotic

KW - Denmark/epidemiology

KW - Adult

KW - Female

KW - Registries

KW - Aged

KW - Population Surveillance

U2 - 10.1159/000488384

DO - 10.1159/000488384

M3 - Journal article

C2 - 29719285

VL - 139

SP - 195

EP - 198

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 3

ER -

Andersen MA, Bjerrum OW, Ranjan A, Skov V, Kruse TA, Thomassen M et al. Myeloproliferative Neoplasms in Danish Twins. Acta Haematologica. 2018 maj 3;139(3):195-198. https://doi.org/10.1159/000488384